ZFIN is now using GRCz12tu for Genomic Data

Gene

paf1

ID

ZDB-GENE-050506-101

Name

PAF1 homolog, Paf1/RNA polymerase II complex component

Symbol

paf1 Nomenclature History

Previous Names

paf1l
aln
im:6906070 (1)
wu:fb80a09

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Involved in heart development and neural crest cell development. Located in nucleus. Part of Cdc73/Paf1 complex. Orthologous to human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6906070 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
hi3789Tg	Transgenic insertion	Intron 2	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa22734	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
z12Tg	Transgenic insertion	Unknown	Unknown	DNA
z24	Allele with one point mutation	Unknown	Premature Stop	ENU

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
MO1-paf1	N/A	(2)
MO2-paf1	N/A	Langenbacher et al., 2011

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Human Disease

Associated With paf1 Human Ortholog

No data available

Associated With paf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007133	RNA polymerase II associated factor Paf1

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Domain Details Per Protein

Protein	Additional Resources	Length	RNA polymerase II associated factor Paf1
UniProtKB:Q4U0S5	InterPro	503

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Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	paf1-201 (1) Ensembl	Ensembl		1,221 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-paf1	polyclonal	paf1	IgG	Rabbit	WB	Bethyl Laboratories, Inc.	2

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Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Encodes	EST	fb80a09	AI545272 AI558751
Encodes	EST	IMAGE:6906070	CB362926	Thisse et al., 2004
Encodes	cDNA	MGC:162706	BC139613	ZFIN Curated Data

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Sequences

Genome Browsers

NCBI

Genome Assembly: GRCz12tuChromosome: 15

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001024453 (1)	2439 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:JBMGRA010000015 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl
Polypeptide	UniProtKB:Q4U0S5 (1)	503 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PAF1	19	Ensembl:ENSG00000006712 Gene:54623 HGNC:25459 OMIM:610506	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Paf1	7	Ensembl:ENSMUSG00000003437 Gene:54624 MGI:1923988	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

No data available