Gene
kif3a
- ID
- ZDB-GENE-050417-71
- Name
- kinesin family member 3A
- Symbol
- kif3a Nomenclature History
- Previous Names
-
- fc55h04
- wu:fc55h04
- zgc:110284
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Part of kinesin complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human KIF3A (kinesin family member 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la012523Tg | Transgenic insertion | Unknown | Unknown | DNA | |
ouc2004 | Allele with one deletion | Exon 4 | Premature Stop | CRISPR | |
pd1084 | Allele with one point mutation | Unknown | Splicing Variant | ENU | |
sa1617 | Allele with one point mutation | Exon 9 | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-kif3a | (3) | |
CRISPR2-kif3a | Xie et al., 2022 | |
CRISPR3-kif3a | Xie et al., 2022 | |
MO1-kif3a | N/A | (3) |
MO2-kif3a | N/A | Khan et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
Domain | IPR001752 | Kinesin motor domain |
Family | IPR027640 | Kinesin-like protein |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|
UniProtKB:E9QB71 | InterPro | 701 | |||||
UniProtKB:A0A8M9QB16 | InterPro | 436 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-20F11 | ZFIN Curated Data | |
Encodes | EST | fc55h04 | ||
Encodes | cDNA | MGC:110284 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192509 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001017604 (1) | 2875 nt | ||
Genomic | GenBank:CU179640 (2) | 158947 nt | ||
Polypeptide | UniProtKB:E9QB71 (1) | 701 aa |
- Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
- Xie, H., Wang, X., Jin, M., Li, L., Zhu, J., Kang, Y., Chen, Z., Sun, Y., Zha, C. (2022) Cilia regulate meiotic recombination in zebrafish. Journal of molecular cell biology. 14(7)
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Zhu, P., Xu, J., Wang, Y., Zhao, C. (2021) Loss of Ift74 Leads to Slow Photoreceptor Degeneration and Ciliogenesis Defects in Zebrafish. International Journal of Molecular Sciences. 22(17):
- Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Feng, D., Chen, Z., Yang, K., Miao, S., Xu, B., Kang, Y., Xie, H., Zhao, C. (2017) The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. The Journal of biological chemistry. 292(42):17375-17386
- Khan, S.Y., Vasanth, S., Kabir, F., Gottsch, J.D., Khan, A.O., Chaerkady, R., Lee, M.W., Leitch, C.C., Ma, Z., Laux, J., Villasmil, R., Khan, S.N., Riazuddin, S., Akram, J., Cole, R.N., Talbot, C.C., Pourmand, N., Zaghloul, N.A., Hejtmancik, J.F., Riazuddin, S.A. (2016) FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Nature communications. 7:10953
- Pooranachandran, N., Malicki, J.J. (2016) Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 203(2):771-85
- Raghupathy, R.K., Zhang, X., Alhasani, R.H., Zhou, X., Mullin, M., Reilly, J., Li, W., Liu, M., Shu, X. (2016) Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish. Cell biochemistry and function. 34(6):429-40
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