Gene

wdr73

ID

ZDB-GENE-050417-126

Name

WD repeat domain 73

Symbol

wdr73 Nomenclature History

Previous Names

zgc:112071 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within cerebellar Purkinje cell differentiation and midbrain development. Predicted to be located in cleavage furrow and spindle. Predicted to be active in cytoplasm. Predicted to colocalize with cytosol and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112071 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Ben-Omran et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr73 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Galloway-Mowat syndrome 1	Alliance	Galloway-Mowat syndrome 1	251300

Associated With wdr73 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR042795	WD repeat-containing protein 73
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat