Gene
cdh6
- ID
- ZDB-GENE-050320-92
- Name
- cadherin 6
- Symbol
- cdh6 Nomenclature History
- Previous Names
-
- zgc:103673
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity and cadherin binding activity. Acts upstream of or within lateral line ganglion development; pronephros development; and retina morphogenesis in camera-type eye. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including nervous system; neural crest cell; pronephros; trigeminal placode; and trunk mesenchyme. Orthologous to several human genes including CDH6 (cadherin 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19781 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdh6 | Tsai et al., 2020 | |
| CRISPR2-cdh6 | Tsai et al., 2020 | |
| CRISPR3-cdh6 | Tsai et al., 2020 | |
| CRISPR4-cdh6 | Tsai et al., 2020 | |
| CRISPR5-cdh6 | Tsai et al., 2020 | |
| MO1-cdh6 | N/A | (4) |
| MO2-cdh6 | N/A | Kubota et al., 2007 |
| MO3-cdh6 | N/A | (2) |
| MO4-cdh6 | N/A | Clay et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5WN09 | InterPro | 794 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151M6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103673 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013520 (1) | 4275 nt | ||
| Genomic | GenBank:CR925777 (1) | 210659 nt | ||
| Polypeptide | UniProtKB:Q5WN09 (1) | 794 aa |
- Chen, H.J., Barske, L., Talbot, J.C., Dinwoodie, O.M., Roberts, R.R., Farmer, D.T., Jimenez, C., Merrill, A.E., Tucker, A.S., Crump, J.G. (2023) Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Developmental Cell. 58(6):461-473.e7
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Wang, M., Chen, Y., Zhu, M., Xu, B., Guo, W., Lyu, Y., Zhang, C. (2019) Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and comparative endocrinology. 282:113219
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, X., Zheng, Y., Zhang, Y., Li, J., Zhang, H., Wang, H. (2016) Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Chemosphere. 144:2195-2205
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, Q., Bhattarai, S., Wang, N., Sochacka-Marlowe, A. (2015) Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain. The Journal of comparative neurology. 523(9):1419-42
- Xing, C., Gong, B., Xue, Y., Han, Y., Wang, Y., Meng, A., Jia, S. (2015) TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. Journal of molecular cell biology. 7(1):48-61
- Zecca, A., Dyballa, S., Voltes, A., Bradley, R., Pujades, C. (2015) The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:7475-86
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