Gene
msi1b
- ID
- ZDB-GENE-050320-86
- Name
- musashi RNA binding protein 1b
- Symbol
- msi1b Nomenclature History
- Previous Names
-
- msi1
- fb40b12
- wu:fb40b12
- zgc:103751
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within central nervous system development. Predicted to be active in cytoplasm. Is expressed in central nervous system; eye; and immature eye. Orthologous to human MSI1 (musashi RNA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103751 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shibata et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010184Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026548Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026549Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-msi1b | N/A | Shibata et al., 2012 |
| MO2-msi1b | N/A | Shibata et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR034126 | RNA-binding protein Musashi homologue, RNA recognition motif 2 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA-binding protein Musashi homologue, RNA recognition motif 2 | RNA recognition motif domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q5BKV4 | InterPro | 330 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-63D15 | ZFIN Curated Data | |
| Encodes | EST | fb40b12 | ||
| Encodes | cDNA | MGC:103751 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191536 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013516 (1) | 2309 nt | ||
| Genomic | GenBank:BX005328 (2) | 272840 nt | ||
| Polypeptide | UniProtKB:Q5BKV4 (1) | 330 aa |
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Jacob, A.E., Turner, C.E., Amack, J.D. (2016) Evolution and Expression of Paxillin Genes in Teleost Fish. PLoS One. 11:e0165266
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hochgreb-Hägele, T., Koo, D.E., Das, N.M., and Bronner, M.E. (2014) Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Stem cells (Dayton, Ohio). 32(2):558-571
- Jászai, J., Graupner, S., Tanaka, E.M., Funk, R.H., Huttner, W.B., Brand, M., and Corbeil, D. (2013) Spatial Distribution of Prominin-1 (CD133) - Positive Cells within Germinative Zones of the Vertebrate Brain. PLoS One. 8(5):e63457
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Shibata, S., Umei, M., Kawahara, H., Yano, M., Makino, S., and Okano, H. (2012) Characterization of the RNA-binding protein Musashi1 in zebrafish. Brain research. 1462:162-173
- Jászai, J., Fargeas, C.A., Graupner, S., Tanaka, E.M., Brand, M., Huttner, W.B., and Corbeil, D. (2011) Distinct and Conserved Prominin-1/CD133-Positive Retinal Cell Populations Identified across Species. PLoS One. 6(3):e17590
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