Gene
matn1
- ID
- ZDB-GENE-050307-3
- Name
- matrilin 1
- Symbol
- matn1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within cartilage development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including cartilage element; head; integument; notochord; and pectoral fin. Orthologous to human MATN1 (matrilin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Neacsu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020858Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-matn1 | N/A | Neacsu et al., 2014 |
| MO2-matn1 | N/A | Neacsu et al., 2014 |
| MO3-matn1 | N/A | Neacsu et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding domain | EGF-like domain | Extracellular Matrix Assembly and Organization | Matrilin, coiled-coil domain superfamily | Matrilin, coiled-coil trimerisation domain | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5WWJ4 | InterPro | 489 | |||||||
| UniProtKB:A0A8M9PN77 | InterPro | 446 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-181O15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-188M11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099740 (1) | 2057 nt | ||
| Genomic | GenBank:CU104776 (2) | 106546 nt | ||
| Polypeptide | UniProtKB:A5WWJ4 (1) | 489 aa |
- Nayak, P.K., Subramanian, A., Schilling, T.F. (2025) Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes. eLIFE. 14:
- Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):
- Hawkey-Noble, A., Pater, J.A., Kollipara, R., Fitzgerald, M., Maekawa, A.S., Kovacs, C.S., Young, T.L., French, C.R. (2022) Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis. Genes. 13(7):
- Norcross, R.G., Abdelmoti, L., Rouchka, E.C., Andreeva, K., Tussey, O., Landestoy, D., Galperin, E. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology. 492:156-171
- Henson, H.E., Taylor, M.R. (2020) A sart1 Zebrafish Mutant Results in Developmental Defects in the Central Nervous System. Cells. 9(11):
- Jia, S., Wu, X., Wu, Y., Cui, X., Tao, B., Zhu, Z., Hu, W. (2020) Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome. International journal of biological sciences. 16:3039-3049
- Ng, P.C.I., Chan, J.Y.W., Leung, R.K.K., Li, J., Ren, Z., Chan, A.W.H., Xu, Y., Lee, S.S., Wang, R., Ji, X., Zheng, J., Chan, D.P.C., Yew, W.W., Lee, S.M.Y. (2020) Role of oxidative stress in clofazimine-induced cardiac dysfunction in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 132:110749
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12)
- Askary, A., Smeeton, J., Paul, S., Schindler, S., Braasch, I., Ellis, N.A., Postlethwait, J., Miller, C.T., Crump, J.G. (2016) Ancient origin of lubricated joints in bony vertebrates. eLIFE. 5
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