Gene
prkcaa
- ID
- ZDB-GENE-050208-100
- Name
- protein kinase C, alpha, a
- Symbol
- prkcaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood coagulation. Predicted to be located in mitochondrial membrane; nucleus; and plasma membrane. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139045 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Williams et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pituitary tumor, invasive |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Classical Protein Kinase C alpha, catalytic domain | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C, alpha/beta/gamma types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QIY5 | InterPro | 670 | |||||||||||||
| UniProtKB:A0A8M9PM31 | InterPro | 679 |
1 - 2 of 2
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkca-001
(1)
|
Ensembl | 2,172 nt | ||
| mRNA |
prkcaa-202
(1)
|
Ensembl | 6,143 nt |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-prkca | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
6 | |
| Ab1-prkca | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
28 |
1 - 2 of 2
Plasmids
No data available