Gene
gcm2
- ID
- ZDB-GENE-050127-1
- Name
- glial cells missing transcription factor 2
- Symbol
- gcm2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cartilage development; epidermal cell fate specification; and sodium ion homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; macrophage; pharynx; and yolk. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-gcm2 | N/A | Hogan et al., 2004 |
MO2-gcm2 | N/A | Hogan et al., 2004 |
MO3-gcm2 | N/A | Hogan et al., 2004 |
MO4-gcm2 | N/A | (2) |
MO5-gcm2 | N/A | (12) |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003902 | Transcription regulator GCM domain |
Family | IPR039791 | Chorion-specific transcription factor GCM |
Homologous_superfamily | IPR036115 | GCM domain superfamily |
Homologous_superfamily | IPR043020 | GCM domain, large subdomain |
Homologous_superfamily | IPR043021 | GCM, small domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Chorion-specific transcription factor GCM | GCM domain, large subdomain | GCM domain superfamily | GCM, small domain | Transcription regulator GCM domain |
---|---|---|---|---|---|---|---|
UniProtKB:Q68BU9 | InterPro | 496 | |||||
UniProtKB:Q5TLZ9 | InterPro | 478 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:gcm2-EGFP) |
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-203G10 | ZFIN Curated Data | |
Contains | STS | unp1185 | Hanaoka et al., 2004 | |
Encodes | cDNA | MGC:193909 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001005603 (1) | 2035 nt | ||
Genomic | GenBank:BX546453 (1) | 160383 nt | ||
Polypeptide | UniProtKB:Q68BU9 (1) | 496 aa |
- Fang, Y., Wan, J.P., Wang, Z., Song, S.Y., Zhang, C.X., Yang, L., Zhang, Q.Y., Yan, C.Y., Wu, F.Y., Lu, S.Y., Sun, F., Han, B., Zhao, S.X., Dong, M., Song, H.D. (2024) Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. Nature communications. 15:31653165
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Shih, S.W., Yan, J.J., Tsou, Y.L., Lu, S.W., Wang, M.C., Chou, M.Y., Hwang, P.P. (2022) In Vivo Functional Assay in Fish Gills: Exploring Branchial Acid-Excreting Mechanisms in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T. (2021) Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Developmental Cell. 56(9):1296-1312.e7
- Lin, L.Y., Hung, G.Y., Yeh, Y.H., Chen, S.W., Horng, J.L. (2019) Acidified water impairs the lateral line system of zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 217:105351
- Lawir, D.F., Iwanami, N., Schorpp, M., Boehm, T. (2017) A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Scientific Reports. 7:44145
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
- Kwong, R.W., Perry, S.F. (2016) A role for sodium-chloride cotransporters in the rapid regulation of ion uptake following acute environmental acidosis: New insights from the zebrafish model. American journal of physiology. Cell physiology. 311(6):C931-C941
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