Gene
foxj1b
- ID
- ZDB-GENE-041212-76
- Name
- forkhead box J1b
- Symbol
- foxj1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic organ morphogenesis and motile cilium assembly. Predicted to be active in nucleus. Is expressed in several structures, including axis; germ ring; mesoderm; nervous system; and pronephros. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la012142Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la018100Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9105 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22082 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sq5719 | Allele with one delins | Unknown | Unknown | CRISPR | |
tsu10Gt | Transgenic insertion | Unknown | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-foxj1b | (2) | |
CRISPR2-foxj1b | (2) | |
MO1-foxj1b | N/A | Tian et al., 2009 |
MO2-foxj1b | N/A | Tian et al., 2009 |
MO3-foxj1b | N/A | (2) |
MO4-foxj1b | N/A | Yu et al., 2011 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
primary ciliary dyskinesia 43 | Alliance | Ciliary dyskinesia, primary, 43 | 618699 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box protein J1 | Forkhead box protein J1, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1R8Z9 | InterPro | 442 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxj1b-201
(1)
|
Ensembl | 2,316 nt | ||
mRNA |
foxj1b-202
(1)
|
Ensembl | 828 nt | ||
mRNA |
foxj1b-203
(1)
|
Ensembl | 1,343 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:foxj1b-HA) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-197A13 | ZFIN Curated Data | |
Encodes | EST | fj67h07 | ||
Encodes | cDNA | MGC:101713 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192900 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001008648 (1) | 2352 nt | ||
Genomic | GenBank:CR318663 (1) | 28607 nt | ||
Polypeptide | UniProtKB:F1R8Z9 (1) | 442 aa |
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Mytlis, A., Kumar, V., Qiu, T., Deis, R., Hart, N., Levy, K., Masek, M., Shawahny, A., Ahmad, A., Eitan, H., Nather, F., Adar-Levor, S., Birnbaum, R.Y., Elia, N., Bachmann-Gagescu, R., Roy, S., Elkouby, Y.M. (2022) Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium. Science (New York, N.Y.). 376(6599):eabh3104
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- D'Gama, P.P., Qiu, T., Cosacak, M.I., Rayamajhi, D., Konac, A., Hansen, J.N., Ringers, C., Acuña-Hinrichsen, F., Hui, S.P., Olstad, E.W., Chong, Y.L., Lim, C.K.A., Gupta, A., Ng, C.P., Nilges, B.S., Kashikar, N.D., Wachten, D., Liebl, D., Kikuchi, K., Kizil, C., Yaksi, E., Roy, S., Jurisch-Yaksi, N. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Reports. 37:109775
- Rajan, S.G., Nacke, L.M., Dhingra, J.S., Saxena, A. (2021) Notch signaling mediates olfactory multiciliated cell specification. Cells & development. 168:203715
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
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