Gene

pink1

ID
ZDB-GENE-041212-53
Name
PTEN induced kinase 1
Symbol
pink1 Nomenclature History
Previous Names
  • wu:fc39e12
  • zgc:101729 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and swimming behavior. Located in cytosol and mitochondrion. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
40 figures from 13 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pink1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 6 Alliance Parkinson disease 6, early onset 605909
1 - 1 of 1
Associated With pink1 Via Experimental Models
Human Disease Fish Conditions Citations
Parkinson's disease AB + MO1-pink1 + MO2-pink1 standard conditions Anichtchik et al., 2008
Parkinson's disease pink1zf1035/zf1035 standard conditions Matsui et al., 2017
Parkinson's disease pink1sh397/sh397 (AB) standard conditions Soman et al., 2019
early-onset Parkinson's disease pink1sh397/sh397 standard conditions Soman et al., 2017
1 - 4 of 4
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR040110 PINK1, protein kinase domain
Family IPR051511 Mitochondrial Quality Control and Scaffold Kinases
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Mitochondrial Quality Control and Scaffold Kinases PINK1, protein kinase domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q5PRB2 InterPro 574
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pink1-201 (1)
Ensembl
Ensembl 4,010 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pink1 polyclonal IgG Rabbit
  • IHC
  • WB
 Cayman Chemical Company
7
1 - 1 of 1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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