Gene
pink1
- ID
- ZDB-GENE-041212-53
- Name
- PTEN induced kinase 1
- Symbol
- pink1 Nomenclature History
- Previous Names
-
- wu:fc39e12
- zgc:101729 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and swimming behavior. Located in cytosol and mitochondrion. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101729 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 13 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parkinson's disease 6 | Alliance | Parkinson disease 6, early onset | 605909 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR040110 | PINK1, protein kinase domain |
| Family | IPR051511 | Mitochondrial Quality Control and Scaffold Kinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial Quality Control and Scaffold Kinases | PINK1, protein kinase domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5PRB2 | InterPro | 574 |
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- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pink1 | polyclonal | IgG | Rabbit |
|
Cayman Chemical Company
|
7 |
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Plasmids
- Bagwell, E., Shin, M., Henkel, N., Migliaccio, D., Peng, C., Larsen, J. (2024) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated adult zebrafish as a model for Parkinson's Disease. Neuroscience letters. 842:137991
- Grepper, D., Tabasso, C., Zanou, N., Aguettaz, A.K.F., Castro-Sepulveda, M., Ziegler, D.V., Lagarrigue, S., Arribat, Y., Martinotti, A., Ebrahimi, A., Daraspe, J., Fajas, L., Amati, F. (2024) BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function. iScience. 27:110510110510
- Hedayatikatouli, F., Kalyn, M., Elsaid, D., Mbesha, H.A., Ekker, M. (2024) Neuroprotective Effects of Ascorbic Acid, Vanillic Acid, and Ferulic Acid in Dopaminergic Neurons of Zebrafish. Biomedicines. 12(11):
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Zheng, N., Liao, T., Zhang, C., Zhang, Z., Yan, S., Xi, X., Ruan, F., Yang, C., Zhao, Q., Deng, W., Huang, J., Huang, Z.T., Chen, Z.F., Wang, X., Qu, Q., Zuo, Z., He, C. (2024) Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(46):e2406343
- Cansiz, D., Unal, I., Beler, M., Ustundag, U.V., Ak, E., Emekli-Alturfan, E., Alturfan, A.A. (2023) The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish. Neurotoxicology. 99:14-23
- Khalili, A., Safarian, N., van Wijngaarden, E., Zoidl, G.S., Zoidl, G.R., Rezai, P. (2023) Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research. 101(12):1814-1825
- Razali, K., Mohd Nasir, M.H., Kumar, J., Mohamed, W.M.Y. (2023) Mitophagy: A Bridge Linking HMGB1 and Parkinson's Disease Using Adult Zebrafish as a Model Organism. Brain sciences. 13(7):
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
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