Gene
bik
- ID
- ZDB-GENE-041210-181
- Name
- BCL2 interacting killer
- Symbol
- bik Nomenclature History
- Previous Names
-
- si:dkey-31f5.6
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Is expressed in eye; gut; kidney; ovary; and trunk. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR024579 | Bcl-2-interacting killer |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Bcl-2-interacting killer |
|---|---|---|---|
| UniProtKB:Q5RGV7 | InterPro | 153 | |
| UniProtKB:Q5RGV6 | InterPro | 154 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31F5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162744 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045038 (1) | 840 nt | ||
| Genomic | GenBank:BX649534 (2) | 205347 nt | ||
| Polypeptide | UniProtKB:Q5RGV6 (1) | 154 aa |
- Xu, W., Liu, X., Li, J., Sun, C., Chen, L., Zhou, J., Li, K., Li, Q., Meng, A., Sun, Q. (2024) ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis. Cell insight. 3:100179100179
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish. Frontiers in nutrition. 9:870343
- Wang, J., Thomas, H.R., Li, Z., Yeo, N.C.F., Scott, H.E., Dang, N., Hossain, M.I., Andrabi, S.A., Parant, J.M. (2021) Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell Death & Disease. 12:659
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
- Gjini, E., Jing, C.B., Nguyen, A.T., Reyon, D., Gans, E., Kesarsing, M., Peterson, J., Pozdnyakova, O., Rodig, S.J., Mansour, M.R., Joung, K., Look, A.T. (2019) Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish. Disease models & mechanisms. 12(5):
- Suraweera, C.D., Caria, S., Järvå, M., Hinds, M.G., Kvansakul, M. (2018) A structural investigation of NRZ mediated apoptosis regulation in zebrafish. Cell Death & Disease. 9:967
- Silva, A.C., Almeida, D.V., Nornberg, B.F., Pereira, J.R., Pires, D.M., Corcini, C.D., Junior, A.S., Marins, L.F. (2017) Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Transgenic Research. 26(1):123-134
- Valcarce, D.G., Vuelta, E., Robles, V., Herráez, M.P. (2017) Paternal exposure to environmental 17-alpha-ethinylestradiol concentrations modifies testicular transcription, affecting the sperm transcript content and the offspring performance in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 193:18-29
- Zhang, J., Sun, P., Kong, T., Yang, F., Guan, W. (2016) Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquatic toxicology (Amsterdam, Netherlands). 170:208-215
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