Gene
opa1
- ID
- ZDB-GENE-041114-7
- Name
- OPA1 mitochondrial dynamin like GTPase
- Symbol
- opa1 Nomenclature History
- Previous Names
-
- fk62d06
- wu:fb77a10
- wu:fk62d06
- zgc:92092
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including GTPase-dependent fusogenic activity; membrane bending activity; and phospholipid binding activity. Acts upstream of or within chordate embryonic development; mitochondrion organization; and ventricular cardiac muscle cell development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in microtubule; mitochondrial intermembrane space; and mitochondrial membrane. Is expressed in brain; eye; retina; retinal photoreceptor layer; and retinal pigmented epithelium. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-opa1 | (2) | |
| CRISPR2-opa1 | (2) | |
| CRISPR3-opa1 | McQuate et al., 2023 | |
| CRISPR4-opa1 | McQuate et al., 2023 | |
| CRISPR5-opa1 | (2) | |
| CRISPR6-opa1 | (2) | |
| MO1-opa1 | N/A | (4) |
| MO2-opa1 | N/A | Rahn et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Behr syndrome | Alliance | Behr syndrome | 210000 |
| dominant optic atrophy plus syndrome | Alliance | Optic atrophy plus syndrome | 125250 |
| mitochondrial DNA depletion syndrome 14 | Alliance | ?Mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type) | 616896 |
| optic atrophy 1 | Alliance | Optic atrophy 1 | 165500 |
| {Glaucoma, normal tension, susceptibility to} | 606657 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin | Dynamin, GTPase domain | Dynamin-like GTPase OPA1, C-terminal | Dynamin, N-terminal | Dynamin-type guanine nucleotide-binding (G) domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z7B4 | InterPro | 1033 | ||||||
| UniProtKB:A0A8M9Q626 | InterPro | 982 | ||||||
| UniProtKB:Q5U3A7 | InterPro | 966 | ||||||
| UniProtKB:A0A8M9QFC7 | InterPro | 911 | ||||||
| UniProtKB:A0A8M9QFC3 | InterPro | 1034 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-opa1 | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
2 | |
| Ab3-opa1 | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196H19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-18A23 | ZFIN Curated Data | |
| Encodes | EST | fb77a10 | ||
| Encodes | EST | fk62d06 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7155623 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7157256 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92092 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007298 (1) | 4296 nt | ||
| Genomic | GenBank:BX004839 (1) | 223000 nt | ||
| Polypeptide | UniProtKB:A0A8M9QFC3 (1) | 1034 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Hedayatikatouli, F., Kalyn, M., Elsaid, D., Mbesha, H.A., Ekker, M. (2024) Neuroprotective Effects of Ascorbic Acid, Vanillic Acid, and Ferulic Acid in Dopaminergic Neurons of Zebrafish. Biomedicines. 12(11):
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- McQuate, A., Knecht, S., Raible, D.W. (2023) Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells. eLIFE. 12:
- Sharma, S., Magnitsky, S., Reesey, E., Schwartz, M., Haroon, S., Lavorato, M., Chan, S., Xiao, R., Wilkins, B.J., Martinez, D., Seiler, C., Falk, M.J. (2023) Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish. Zebrafish. 21(1):28-38
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Burgoyne, T., Toms, M., Way, C., Tracey-White, D., Futter, C.E., Moosajee, M. (2022) Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish. Cells. 11(22):
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