Gene
atf6
- ID
- ZDB-GENE-041014-328
- Name
- activating transcription factor 6
- Symbol
- atf6 Nomenclature History
- Previous Names
-
- fi12h10
- si:ch211-199m3.9
- si:ch211-260g14.1
- wu:fi12h10
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endoplasmic reticulum unfolded protein response and response to hypoxia. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; female organism; liver; and male organism. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 54 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cinaroglu et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028256Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mnu106 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| nju225 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa1154 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23750 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37084 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37085 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43484 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atf6 | Yang et al., 2024 | |
| CRISPR2-atf6 | Yang et al., 2024 | |
| CRISPR3-atf6 | Wang et al., 2024 | |
| CRISPR4-atf6 | Wang et al., 2024 | |
| CRISPR5-atf6 | Wang et al., 2024 | |
| MO1-atf6 | N/A | (4) |
| MO2-atf6 | N/A | (2) |
| MO3-atf6 | N/A | Ji et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| achromatopsia 7 | Alliance | Achromatopsia 7 | 616517 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATF bZIP Transcription Factors | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q5RH85 | InterPro | 653 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199M3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-260G14 | ZFIN Curated Data | |
| Encodes | EST | fi12h10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110519 (1) | 1962 nt | ||
| Genomic | GenBank:BX571790 (1) | 200944 nt | ||
| Polypeptide | UniProtKB:Q5RH85 (1) | 653 aa |
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Fung, C., Miles, L.B., Bryson-Richardson, R.J., Bird, P.I. (2024) Manipulation of Proteostasis Networks in Transgenic ZAAT Zebrafish via CRISPR-Cas9 Gene Editing. Methods in molecular biology (Clifton, N.J.). 2750:193219-32
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Wang, Y., Liu, J., Du, L.Y., Wyss, J.L., Farrell, J.A., Schier, A.F. (2024) Gene module reconstruction identifies cellular differentiation processes and the regulatory logic of specialized secretion in zebrafish. Developmental Cell. :
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Sarkar, H., Lahne, M., Nair, N., Moosajee, M. (2023) Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia. Antioxidants (Basel, Switzerland). 12(9):
- Zhang, Y., Peng, X., Xue, M., Liu, J., Shang, G., Jiang, M., Chen, D., Liu, B., Wang, Y., Jia, X., Xu, J., Zhang, F., Hu, Y. (2023) SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. Biogerontology. 24(5):813-827
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
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