Gene
fabp10a
- ID
- ZDB-GENE-020318-1
- Name
- fatty acid binding protein 10a, liver basic
- Symbol
- fabp10a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables bile acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 130 figures from 90 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103719 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fabp10a | Zebrafish Nomenclature Committee | |
| CRISPR2-fabp10a | Takada et al., 2017 | |
| CRISPR3-fabp10a | (2) | |
| CRISPR4-fabp10a | (2) | |
| CRISPR5-fabp10a | DiNapoli et al., 2020 |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein |
|---|---|---|---|---|---|
| UniProtKB:B2GQZ3 | InterPro | 126 | |||
| UniProtKB:Q9I8L5 | InterPro PDB | 126 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fabp10a-201
(1)
|
Ensembl | 525 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.8fabp10a:EGFP) |
|
| 2 | (86) | |
| Tg(fabp10a:CFP-NTR) |
|
| 2 | (34) | |
| Tg(-2.7fabp10a:Hsa.CYP3A4-mCherry) |
|
| 1 | Poon et al., 2017 | |
| Tg(-2.8fabp10a:acsl4a,cryaa:mCherry) |
|
| 1 | Freeburg et al., 2024 | |
| Tg(-2.8fabp10a:CAAX-EGFP) |
|
| 1 | (9) | |
| Tg(-2.8fabp10a:Cre,cryaa:Venus) |
|
| 2 | (8) | |
| Tg(-2.8fabp10a:dnvdra,cryaa:Cerulean) |
|
| 1 | Freeburg et al., 2024 | |
| Tg(-2.8fabp10a:EGFP-2A-sav1) |
|
| 1 | Brandt et al., 2020 | |
| Tg(-2.8fabp10a:EGFP-psmd10) |
|
| 3 | (4) | |
| Tg(-2.8fabp10a:EGFP-yy1b) |
|
| 3 | (4) |
1 - 10 of 163
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-135D14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92741 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103719 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192103 | ZFIN Curated Data | |
| interacts with | Promoter | fabp10a_promoter | Laprairie et al., 2017 |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152960 (1) | 441 nt | ||
| Genomic | GenBank:CR293507 (1) | 178271 nt | ||
| Polypeptide | UniProtKB:B2GQZ3 (1) | 126 aa |
No data available
- Gu, X., Yuan, L., Gan, L., Zhang, Z., Zhou, S., Fu, Z., Liu, Y., Xin, Z., Cheng, S., Zhou, X., Yan, H., Wang, Q. (2025) Understanding the Role of Exercise and Probiotic Interventions on Non-Alcoholic Fatty Liver Disease Alleviation in Zebrafish: Dialogue Between the Gut and Liver. International Journal of Molecular Sciences. 26:
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Deng, Z., Ran, Q., Chang, W., Li, C., Li, B., Huang, S., Huang, J., Zhang, K., Li, Y., Liu, X., Liang, Y., Guo, Z., Huang, S. (2024) Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Frontiers in cell and developmental biology. 12:14297821429782
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Hu, Y., Luo, Z., Wang, M., Wu, Z., Liu, Y., Cheng, Z., Sun, Y., Xiong, J.W., Tong, X., Zhu, Z., Zhang, B. (2024) Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 52(1):66-77
- Inoue, M., Sebastian, W.A., Sonoda, S., Miyahara, H., Shimizu, N., Shiraishi, H., Maeda, M., Yanagi, K., Kaname, T., Hanada, R., Hanada, T., Ihara, K. (2024) Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy. Orphanet journal of rare diseases. 19:219219
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Tan, V.W.T., Salmi, T.M., Karamalakis, A.P., Gillespie, A., Ong, A.J.S., Balic, J.J., Chan, Y.C., Bladen, C.E., Brown, K.K., Dawson, M.A., Cox, A.G. (2024) SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental Cell. 59(7):898-910.e6
- Tanwar, P., Bhattacharya, D., Dasari, A., Bijwe, M., Rana, R., Gupta, I., Minocha, S. (2024) Dynamic gene expression pattern in zebrafish gall bladder - an experimental study. International journal of surgery (London, England). 110(12):7585-7589
1 - 10 of 308
Show