Gene
adcyap1b
- ID
- ZDB-GENE-041010-89
- Name
- adenylate cyclase activating polypeptide 1b
- Symbol
- adcyap1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable neuropeptide hormone activity; peptide hormone receptor binding activity; and pituitary adenylate cyclase activating polypeptide activity. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including basal plate midbrain region; male organism; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101522 (19 images)
- MGC:92555 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adcyap1b | Ma et al., 2023 | |
| CRISPR2-adcyap1b | Ma et al., 2023 | |
| CRISPR3-adcyap1b | Ma et al., 2023 | |
| CRISPR4-adcyap1b | Ma et al., 2023 | |
| MO1-adcyap1b | N/A | Wu et al., 2006 |
| MO2-adcyap1b | N/A | (3) |
| MO3-adcyap1b | N/A | Eneman et al., 2017 |
| MO4-adcyap1b | N/A | Ma et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucagon/GIP/secretin/VIP | VIP/GHRH-like |
|---|---|---|---|---|
| UniProtKB:Q5XJ02 | InterPro | 140 | ||
| UniProtKB:Q98TU3 | InterPro | 175 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adcyap1b-201
(1)
|
Ensembl | 3,222 nt | ||
| mRNA |
adcyap1b-202
(1)
|
Ensembl | 884 nt | ||
| mRNA |
adcyap1b-204
(1)
|
Ensembl | 3,435 nt | ||
| mRNA |
adcyap1b-205
(1)
|
Ensembl | 3,330 nt | ||
| ncRNA |
adcyap1b-003
(1)
|
Ensembl | 658 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-adcyap1 | polyclonal | Rabbit |
|
1 | |||
| Ab1-adcyap1b | polyclonal | Chicken |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:adcyap1b) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-212M21 | ZFIN Curated Data | |
| Encodes | EST | fj30e08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92555 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101522 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192041 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214715 (1) | 3268 nt | ||
| Genomic | GenBank:BX927088 (1) | 201361 nt | ||
| Polypeptide | UniProtKB:Q98TU3 (1) | 175 aa |
- Cigliola, V., Shoffner, A., Lee, N., Ou, J., Gonzalez, T.J., Hoque, J., Becker, C.J., Han, Y., Shen, G., Faw, T.D., Abd-El-Barr, M.M., Varghese, S., Asokan, A., Poss, K.D. (2023) Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Nature communications. 14:48574857
- Leid, J., Gray, R., Rakita, P., Koenig, A.L., Tripathy, R., Fitzpatrick, J.A.J., Kaufman, C., Solnica-Krezel, L., Lavine, K.J. (2023) Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism. Biology Open. 12(7):
- Ma, X., Guo, R., Xu, H., Ma, Y., Zhang, R., Liu, X., Zhang, J., Han, Y. (2023) Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish. Journal of thrombosis and haemostasis : JTH. 22(4):951-964
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Van Der Meulen, K.L., Vöcking, O., Weaver, M.L., Meshram, N.N., Famulski, J.K. (2020) Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development. Frontiers in cell and developmental biology. 8:379
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Marvel, M.M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2019) Knockout of Gnrh2 in zebrafish (Danio rerio) reveals its roles in regulating feeding behavior and oocyte quality. General and comparative endocrinology. 280:15-23
- Nakamachi, T., Tanigawa, A., Konno, N., Shioda, S., Matsuda, K. (2019) Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish. Frontiers in endocrinology. 10:227
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
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