Gene
mep1a.2
- ID
- ZDB-GENE-041001-208
- Name
- meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
- Symbol
- mep1a.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within positive regulation of angiogenesis. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including epidermis; gill; heart; liver; and pleuroperitoneal region. Orthologous to human MEP1A (meprin A subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Schütte et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001506 | Peptidase M12A |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Family | IPR008294 | Meprin alpha/beta subunit |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | MAM domain | MATH/TRAF domain | Meprin alpha/beta subunit | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase | TRAF-like |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DKP9 | InterPro | 689 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mep1a.2-201
(1)
|
Ensembl | 2,396 nt | ||
| mRNA |
mep1a.2-202
(1)
|
Ensembl | 2,694 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mep1a.2 | polyclonal |
|
1 |
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and mep1a.1 (ZDB-GENE-041001-209) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.