Gene
cfap298
- ID
- ZDB-GENE-040930-8
- Name
- cilia and flagella associated protein 298
- Symbol
- cfap298 Nomenclature History
- Previous Names
-
- cfap298
- c10h21orf59
- c21orf59
- c21orf59l
- grb
- Kurly (1)
- sb:cb615
- unm tj271
- unm tm304
- unm_tj271
- zgc:64057
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including central canal development; cerebrospinal fluid circulation; and motile cilium assembly. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Is expressed in several structures, including Kupffer's vesicle; axis; mesoderm; pronephros; and sensory system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb615 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cfap298 | Bearce et al., 2022 | |
| CRISPR2-cfap298 | Bearce et al., 2022 | |
| CRISPR3-cfap298 | Bearce et al., 2022 | |
| CRISPR4-cfap298 | Bearce et al., 2022 | |
| MO1-cfap298 | N/A | Austin-Tse et al., 2013 |
| MO2-cfap298 | N/A | (3) |
| MO3-cfap298 | N/A | Jaffe et al., 2016 |
1 - 7 of 7
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 26 | Alliance | Ciliary dyskinesia, primary, 26 | 615500 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR021298 | Cilia- and flagella-associated protein 298 |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Cilia- and flagella-associated protein 298 |
|---|---|---|---|
| UniProtKB:B7ZVU8 | InterPro | 290 | |
| UniProtKB:Q6DRC3 | InterPro | 290 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cfap298-201
(1)
|
Ensembl | 1,520 nt | ||
| mRNA |
cfap298-202
(1)
|
Ensembl | 1,748 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18A10 | ZFIN Curated Data | |
| Encodes | EST | cb615 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:64057 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174534 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198440 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198442 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200088 (1) | 1509 nt | ||
| Genomic | GenBank:CR759796 (2) | 130961 nt | ||
| Polypeptide | UniProtKB:B7ZVU8 (1) | 290 aa |
- Djenoune, L., Mahamdeh, M., Truong, T.V., Nguyen, C.T., Fraser, S.E., Brueckner, M., Howard, J., Yuan, S. (2023) Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Science (New York, N.Y.). 379:717871-78
- Bearce, E.A., Irons, Z.H., Craig, S.B., Kuhns, C.J., Sabazali, C., Farnsworth, D.R., Miller, A.C., Grimes, D.T. (2022) Daw1 regulates the timely onset of cilia motility during development. Development (Cambridge, England). 149(12)
- Bearce, E.A., Irons, Z.H., O'Hara-Smith, J.R., Kuhns, C.J., Fisher, S.I., Crow, W.E., Grimes, D.T. (2022) Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology. eLIFE. 11:
- Laura, M.H., Yasmine, C.B., Raphaël, P., Lotfi, S., Hugues, P.M. (2021) The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS. Scientific Reports. 11:7392
- Orts-Del'Immagine, A., Cantaut-Belarif, Y., Thouvenin, O., Roussel, J., Baskaran, A., Langui, D., Koëth, F., Bivas, P., Lejeune, F.X., Bardet, P.L., Wyart, C. (2020) Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo. Current biology : CB. 30(5):827-839.e4
- Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Carbo-Tano, M., Verweij, F., Jurisch-Yaksi, N., Bardet, P.L., van Niel, G., Gallaire, F., Wyart, C. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. 9:
- Cantaut-Belarif, Y., Sternberg, J.R., Thouvenin, O., Wyart, C., Bardet, P.L. (2018) The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Current biology : CB. 28(15):2479-2486.e4
- Sternberg, J.R., Prendergast, A.E., Brosse, L., Cantaut-Belarif, Y., Thouvenin, O., Orts-Del'Immagine, A., Castillo, L., Djenoune, L., Kurisu, S., McDearmid, J.R., Bardet, P.L., Boccara, C., Okamoto, H., Delmas, P., Wyart, C. (2018) Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature communications. 9:3804
- Grimes, D.T., Boswell, C.W., Morante, N.F., Henkelman, R.M., Burdine, R.D., Ciruna, B. (2016) Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science (New York, N.Y.). 352:1341-4
- Jaffe, K.M., Grimes, D.T., Schottenfeld-Roames, J., Werner, M.E., Ku, T.J., Kim, S.K., Pelliccia, J.L., Morante, N.F., Mitchell, B.J., Burdine, R.D. (2016) c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Reports. 14(8):1841-9
1 - 10 of 20
Show