Gene
rbfox1l
- ID
- ZDB-GENE-040923-2
- Name
- RNA binding fox-1 homolog 1, like
- Symbol
- rbfox1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables RNA binding activity. Acts upstream of or within several processes, including RNA splicing; regulation of RNA splicing; and striated muscle cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; fin bud; musculature system; paraxial mesoderm; and skeletal muscle satellite cell.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
chb5 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
la012929Tg | Transgenic insertion | Unknown | Unknown | DNA | |
re24 | Allele with one delins | Unknown | Unknown | CRISPR | |
sa12116 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44854 | Allele with one point mutation | Unknown | Unknown | ENU | |
tsu054Gt | Transgenic insertion | Intron 1 | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-rbfox1l | Huang et al., 2022 | |
CRISPR2-rbfox1l | (2) | |
MO1-rbfox1l | N/A | (4) |
MO2-rbfox1l | N/A | Gallagher et al., 2011 |
MO3-rbfox1l | N/A | Gao et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Fox-1 C-terminal domain | FOX1, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA binding protein fox-1 homolog 1-3 | RNA binding protein fox-1 homolog 1-like | RNA recognition motif domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9P7V7 | InterPro | 217 | |||||||
UniProtKB:A0A8M2B4J5 | InterPro | 370 | |||||||
UniProtKB:Q7ZT82 | InterPro | 382 | |||||||
UniProtKB:B3DK66 | InterPro | 382 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
rbfox1l-201
(1)
|
Ensembl | 2,205 nt | ||
ncRNA |
rbfox1l-002
(1)
|
Ensembl | 624 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-rbfox1l | polyclonal | Rabbit |
|
4 |
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Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(myl7:GFP-2A-3xHA-rbfox1l) |
| 1 | Huang et al., 2022 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-57K11 | ZFIN Curated Data | |
Encodes | EST | zeh0082 | ||
Encodes | cDNA | MGC:194909 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194918 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_214775 (1) | 1149 nt | ||
Genomic | GenBank:BX511250 (1) | 189081 nt | ||
Polypeptide | UniProtKB:B3DK66 (1) | 382 aa |
No data available
- Antón-Galindo, E., Adel, M.R., García-González, J., Leggieri, A., López-Blanch, L., Irimia, M., Norton, W.H.J., Brennan, C.H., Fernàndez-Castillo, N., Cormand, B. (2024) Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Translational psychiatry. 14:9999
- Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:19501950
- Liang, Y.L., Hu, Y.X., Li, F.F., You, H.M., Chen, J., Liang, C., Guo, Z.F., Jing, Q. (2024) Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish. Acta Pharmacologica Sinica. :
- Quint, W.H., Tadema, K.C.D., Kokke, N.C.C.J., Meester-Smoor, M.A., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2023) Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Scientific Reports. 13:20172017
- Huang, M., Akerberg, A.A., Zhang, X., Yoon, H., Joshi, S., Hallinan, C., Nguyen, C., Pu, W.T., Haigis, M.C., Burns, C.G., Burns, C.E. (2022) Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nature communications. 13:5877
- Berberoglu, M.A., Gallagher, T.L., Morrow, Z.T., Talbot, J.C., Hromowyk, K.J., Tenente, I.M., Langenau, D.M., Amacher, S.L. (2017) Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Developmental Biology. 424(2):162-180
- Gallagher, T.L., Tietz, K.T., Morrow, Z.T., McCammon, J.M., Goldrich, M.L., Derr, N.L., Amacher, S.L. (2017) Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Developmental Biology. 429(1):225-239
- Gao, C., Ren, S., Lee, J.H., Qiu, J., Chapski, D.J., Rau, C.D., Zhou, Y., Abdellatif, M., Nakano, A., Vondriska, T.M., Xiao, X., Fu, X.D., Chen, J.N., Wang, Y. (2016) RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. The Journal of Clinical Investigation. 126(1):195-206
- Qiu, J., Fan, X., Wang, Y., Jin, H., Song, Y., Han, Y., Huang, S., Meng, Y., Tang, F., Meng, A. (2016) Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Journal of molecular cell biology. 8(4):288-301
- Frese, K.S., Meder, B., Keller, A., Just, S., Haas, J., Vogel, B., Fischer, S., Backes, C., Matzas, M., Köhler, D., Benes, V., Katus, H.A., Rottbauer, W. (2015) RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Journal of Cell Science. 128(16):3030-40
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