Gene

gle1

ID
ZDB-GENE-040831-4
Name
GLE1 RNA export mediator
Symbol
gle1 Nomenclature History
Previous Names
  • gle1l (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable inositol hexakisphosphate binding activity; phospholipid binding activity; and translation initiation factor binding activity. Involved in Schwann cell development and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within several processes, including epithelial cilium movement involved in determination of left/right asymmetry; neurogenesis; and poly(A)+ mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in several structures, including head; intestine; pectoral fin; pectoral fin bud; and trunk musculature. Used to study lethal congenital contracture syndrome 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi4161aTgTransgenic insertionExon 1UnknownDNA
la026464TgTransgenic insertionUnknownUnknownDNA
sa6090Allele with one point mutationUnknownPremature StopENU
sa34278Allele with one point mutationUnknownPremature StopENU
sa34279Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-gle1N/A (4)
MO2-gle1N/A (4)
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Human Disease
Associated With gle1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lethal congenital contracture syndrome 1 Alliance Lethal congenital contracture syndrome 1 253310
Congenital arthrogryposis with anterior horn cell disease 611890
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Associated With gle1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR012476 mRNA export factor GLE1-like
Homologous_superfamily IPR038506 GLE1-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length GLE1-like superfamily mRNA export factor GLE1-like
UniProtKB:B0S5C8 InterPro 694
UniProtKB:B0S5D2 InterPro 717
UniProtKB:Q6DRB1 InterPro 695
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gle1-201 (1) Ensembl 2,637 nt
mRNA gle1-202 (1) Ensembl 2,186 nt
ncRNA gle1-002 (1) Ensembl 387 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-51H9ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGLE19
Amino acid sequence comparison (1)
MouseGle12
Amino acid sequence comparison (1)
Citations
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