Gene
gle1
- ID
- ZDB-GENE-040831-4
- Name
- GLE1 RNA export mediator
- Symbol
- gle1 Nomenclature History
- Previous Names
-
- gle1l (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable inositol hexakisphosphate binding activity; phospholipid binding activity; and translation initiation factor binding activity. Involved in Schwann cell development and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within several processes, including epithelial cilium movement involved in determination of left/right asymmetry; neurogenesis; and poly(A)+ mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in several structures, including head; intestine; pectoral fin; pectoral fin bud; and trunk musculature. Used to study lethal congenital contracture syndrome 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi4161aTg | Transgenic insertion | Exon 1 | Unknown | DNA | |
la026464Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa6090 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34279 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
lethal congenital contracture syndrome 1 | Alliance | Lethal congenital contracture syndrome 1 | 253310 |
Congenital arthrogryposis with anterior horn cell disease | 611890 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
lethal congenital contracture syndrome 1 | gle1hi4161aTg/hi4161aTg (TL) | standard conditions | Seytanoglu et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | GLE1-like superfamily | mRNA export factor GLE1-like |
---|---|---|---|---|
UniProtKB:B0S5C8 | InterPro | 694 | ||
UniProtKB:B0S5D2 | InterPro | 717 | ||
UniProtKB:Q6DRB1 | InterPro | 695 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-51H9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001003885 (1) | 2186 nt | ||
Genomic | GenBank:BX088526 (1) | 187161 nt | ||
Polypeptide | UniProtKB:B0S5D2 (1) | 717 aa |
- Huang, Y., Gao, B.Q., Meng, Q., Yang, L.Z., Ma, X.K., Wu, H., Pan, Y.H., Yang, L., Li, D., Chen, L.L. (2023) CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Genome biology. 24:1515
- Wolf, E.J., Miles, A., Lee, E.S., Nabeel-Shah, S., Greenblatt, J.F., Palazzo, A.F., Tropepe, V., Emili, A. (2020) MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. Cell Reports. 31:107693
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Jao, L.E., Akef, A., Wente, S.R. (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Molecular biology of the cell. 28:120-127
- Seytanoglu, A., Alsomali, N.I., Valori, C.F., McGown, A., Kim, H.R., Ning, K., Ramesh, T., Sharrack, B., Wood, J.D., Azzouz, M. (2016) Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience. 322:287-97
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kaneb, H.M., Folkmann, A.W., Belzil, V.V., Jao, L.E., Leblond, C.S., Girard, S.L., Daoud, H., Noreau, A., Rochefort, D., Hince, P., Szuto, A., Levert, A., Vidal, S., André-Guimont, C., Camu, W., Bouchard, J.P., Dupré, N., Rouleau, G.A., Wente, S.R., Dion, P.A. (2015) Deleterious mutations in the essential mRNA metabolism factor, hGle1, in Amyotrophic Lateral Sclerosis. Human molecular genetics. 24(5):1363-73
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Jao, L.E., Appel, B., and Wente, S.R. (2012) A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development (Cambridge, England). 139(7):1316-1326
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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