Gene
meox1
- ID
- ZDB-GENE-040718-149
- Name
- mesenchyme homeobox 1
- Symbol
- meox1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in hematopoietic stem cell differentiation and somite development. Acts upstream of or within several processes, including developmental pigmentation; muscle cell development; and skeletal system development. Located in nucleus. Is expressed in several structures, including fast muscle myoblast; medial rectus; paraxial mesoderm; pectoral fin; and tail bud. Used to study Klippel-Feil syndrome. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
tm26 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-meox1 | Diamond et al., 2023 | |
CRISPR2-meox1 | Diamond et al., 2023 | |
MO1-meox1 | N/A | Nguyen et al., 2014 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Klippel-Feil syndrome 2 | Alliance | Klippel-Feil syndrome 2 | 214300 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Klippel-Feil syndrome | meox1tm26/tm26 (TU) | standard conditions | Dauer et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein MOX-1/MOX-2 | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:F1Q4R9 | InterPro | 253 | |||||
UniProtKB:A0A8M9PW63 | InterPro | 181 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-102M20 | ZFIN Curated Data | |
Encodes | EST | ibd2838 | ||
Encodes | cDNA | MGC:92343 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001002450 (1) | 2250 nt | ||
Genomic | GenBank:CR847880 (1) | 158507 nt | ||
Polypeptide | UniProtKB:F1Q4R9 (1) | 253 aa |
- Diamond, K.M., Burtner, A.E., Siddiqui, D., Alvarado, K., Leake, S., Rolfe, S., Zhang, C., Kwon, R.Y., Maga, A.M. (2023) Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases. Journal of anatomy. 243(1):66-77
- Bickers, C., Española, S.D., Grainger, S., Pouget, C., Traver, D. (2018) Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 13:e0202747
- Dauer, M.V.P., Currie, P.D., Berger, J. (2018) Skeletal malformations of Meox1-deficient zebrafish resemble human Klippel-Feil syndrome. Journal of anatomy. 233(6):687-695
- Farrell, J.A., Wang, Y., Riesenfeld, S.J., Shekhar, K., Regev, A., Schier, A.F. (2018) Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis. Science (New York, N.Y.). 360(6392)
- Volkening, A., Sandstede, B. (2018) Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns. Nature communications. 9:3231
- Nguyen, P.D., Gurevich, D.B., Sonntag, C., Hersey, L., Alaei, S., Nim, H.T., Siegel, A., Hall, T.E., Rossello, F.J., Boyd, S.E., Polo, J.M., Currie, P.D. (2017) Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest. Cell Stem Cell. 21:107-119.e6
- Pillay, L.M., Mackowetzky, K.J., Widen, S.A., Waskiewicz, A.J. (2016) Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS One. 11:e0166040
- Hiscock, T.W., Megason, S.G. (2015) Mathematically guided approaches to distinguish models of periodic patterning. Development (Cambridge, England). 142:409-19
- Kurian, L., Aguirre, A., Sancho-Martinez, I., Benner, C., Hishida, T., Nguyen, T.B., Reddy, P., Nivet, E., Krause, M.N., Nelles, D.A., Rodriguez Esteban, C., Campistol, J.M., Yeo, G.W., Izpisua Belmonte, J.C. (2015) Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 131:1278-90
- Windner, S.E., Doris, R.A., Ferguson, C.M., Nelson, A.C., Valentin, G., Tan, H., Oates, A.C., Wardle, F.C., Devoto, S.H. (2015) Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish. Development (Cambridge, England). 142(6):1159-68
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