Gene

fzr1a

ID
ZDB-GENE-040426-712
Name
fizzy/cell division cycle 20 related 1a
Symbol
fzr1a Nomenclature History
Previous Names
  • fzr1
  • zgc:55450
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Imai et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa21265Allele with one point mutationUnknownPremature StopENU
sa25392Allele with one point mutationUnknownSplice SiteENU
sa34376Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-fzr1aN/AImai et al., 2010
MO2-fzr1aN/A (2)
MO3-fzr1aN/ARobu et al., 2012
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Human Disease
Associated With fzr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 109 Alliance Developmental and epileptic encephalopathy 109 620145
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Associated With fzr1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR056150 CDC20/Fizzy, WD40 domain
Family IPR033010 WD repeat Cdc20/Fizzy
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length CDC20/Fizzy, WD40 domain WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily WD repeat Cdc20/Fizzy
UniProtKB:Q7ZUP9 InterPro 495
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fzr1a-201 (1) Ensembl 2,118 nt
mRNA fzr1a-202 (1) Ensembl 505 nt
mRNA fzr1a-203 (1) Ensembl 2,430 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-196I15ZFIN Curated Data
Contained inBACCH211-133L5ZFIN Curated Data
EncodescDNAMGC:55450ZFIN Curated Data
EncodescDNAMGC:192445ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFZR119
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseFzr110
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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