Gene
fzr1a
- ID
- ZDB-GENE-040426-712
- Name
- fizzy/cell division cycle 20 related 1a
- Symbol
- fzr1a Nomenclature History
- Previous Names
-
- fzr1
- zgc:55450
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55450 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Imai et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fzr1a | N/A | Imai et al., 2010 |
| MO2-fzr1a | N/A | (2) |
| MO3-fzr1a | N/A | Robu et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 109 | Alliance | Developmental and epileptic encephalopathy 109 | 620145 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR056150 | CDC20/Fizzy, WD40 domain |
| Family | IPR033010 | WD repeat Cdc20/Fizzy |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CDC20/Fizzy, WD40 domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat Cdc20/Fizzy |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUP9 | InterPro | 495 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-196I15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-133L5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55450 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192445 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200253 (1) | 2089 nt | ||
| Genomic | GenBank:BX004774 (1) | 186380 nt | ||
| Polypeptide | UniProtKB:Q7ZUP9 (1) | 495 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Robu, M.E., Zhang, Y., and Rhodes, J. (2012) Rereplication in emi1-Deficient Zebrafish Embryos Occurs through a Cdh1-Mediated Pathway. PLoS One. 7(10):e47658
- Imai, F., Yoshizawa, A., Fujimori-Tonou, N., Kawakami, K., and Masai, I. (2010) The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish. Development (Cambridge, England). 137(19):3257-3268
- Weil, M., Scholz, S., Zimmer, M., Sacher, F., and Duis, K. (2009) Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environmental toxicology and chemistry. 28(9):1970-1978
- Voelker, D., Vess, C., Tillmann, M., Nagel, R., Otto, G.W., Geisler, R., Schirmer, K., and Scholz, S. (2007) Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae. Aquatic toxicology (Amsterdam, Netherlands). 81(4):355-364
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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