Gene
atp2a2a
- ID
- ZDB-GENE-040426-702
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
- Symbol
- atp2a2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable P-type calcium transporter activity. Acts upstream of or within heart looping and regulation of heart contraction. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55380 (12 images)
- IMAGE:7165932 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ebert et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb779 | Allele with one delins | Exon 14 | Unknown | CRISPR | |
sa13962 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27138 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34332 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41137 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-atp2a2a | Yin et al., 2015 | |
CRISPR2-atp2a2a | Zebrafish Nomenclature Committee | |
CRISPR3-atp2a2a | Zebrafish Nomenclature Committee | |
MO1-atp2a2a | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
acrokeratosis verruciformis | Alliance | Acrokeratosis verruciformis | 101900 |
keratosis follicularis | Alliance | Darier disease | 124200 |
{Rhabdomyolysis, susceptibility to, 2} | 621236 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
Family | IPR001757 | P-type ATPase |
Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
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Domain Details Per Protein
Protein | Additional Resources | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7ZW18 | InterPro | 996 | |||||||||||
UniProtKB:A0A8M2BEU8 | InterPro | 1042 | |||||||||||
UniProtKB:A0A8M9QII7 | InterPro | 996 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
aberrant processed transcript |
atp2a2a-202
(1)
|
Ensembl | 798 nt | ||
mRNA |
atp2a2a-201
(1)
|
Ensembl | 3,724 nt | ||
mRNA |
atp2a2a-203
(1)
|
Ensembl | 3,186 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-atp2a2a | polyclonal | IgG | Rabbit |
|
GeneTex
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-252G21 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7165932 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:55380 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193107 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200965 (1) | 3738 nt | ||
Genomic | GenBank:CR407563 (2) | 109914 nt | ||
Polypeptide | UniProtKB:A0A8M2BEU8 (1) | 1042 aa |
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Huang, Y., Wang, W.F., Huang, C.X., Li, X.H., Liu, H., Wang, H.L. (2022) miR-731 modulates the zebrafish heart morphogenesis via targeting Calcineurin/Nfatc3a pathway. Biochimica et biophysica acta. General subjects. 1866(6):130133
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Zhu, L., Wang, C., Jiang, H., Zhang, L., Mao, L., Zhang, Y., Qi, S., Liu, X. (2022) Quizalofop-P-ethyl induced developmental toxicity and cardiotoxicity in early life stage of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 238:113596
- Kuo, M.W., Tsai, H.H., Wang, S.H., Chen, Y.Y., Yu, A.L., Yu, J. (2021) Yulink, predicted from evolutionary analysis, is involved in cardiac function. Journal of Biomedical Science. 28:7
- Sundarrajan, L., Jayakumar Rajeswari, J., Weber, L.P., Unniappan, S. (2021) Nesfatin-1-Like Peptide is a Negative Regulator of Cardiovascular Functions in Zebrafish and Goldfish. General and comparative endocrinology. 313:113892
- Bautista, N.M., Crespel, A., Crossley, J., Padilla, P., Burggren, W. (2020) Parental transgenerational epigenetic inheritance related to dietary crude oil exposure in Danio rerio. The Journal of experimental biology. 223(Pt 16):
- Cunha, V., Vogs, C., Le Bihanic, F., Dreij, K. (2020) Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos. Environment International. 143:105913
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