Gene
cdk2
- ID
- ZDB-GENE-040426-2741
- Name
- cyclin dependent kinase 2
- Symbol
- cdk2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and head. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56598 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdk2 | (2) | |
| CRISPR2-cdk2 | Wang et al., 2021 | |
| CRISPR3-cdk2 | Wang et al., 2021 | |
| MO1-cdk2 | N/A | Yang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050108 | Cyclin-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZWB1 | InterPro | 298 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-182B19 | ZFIN Curated Data | |
| Encodes | EST | fa10c02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56598 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77684 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213406 (1) | 1619 nt | ||
| Genomic | GenBank:CU633767 (2) | 38548 nt | ||
| Polypeptide | UniProtKB:Q7ZWB1 (1) | 298 aa |
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Li, Y., Yan, Y., Gong, B., Zheng, Q., Zhou, H., Sun, J., Li, M., Wang, Z., Li, Y., Wan, Y., Chen, W., Qi, S., Mo, X., Meng, A., Xiang, B., Chen, J. (2024) A Huluwa phosphorylation switch regulates embryonic axis induction. Nature communications. 15:1002810028
- Zhang, S., Yang, J., Xu, J., Li, J., Xu, L., Jin, N., Li, X. (2024) Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks. Molecular neurobiology. :
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., Brazma, A., Ozhan, G. (2023) Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells. Frontiers in cell and developmental biology. 11:12979101297910
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172
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