Gene
ednrab
- ID
- ZDB-GENE-040426-2364
- Name
- endothelin receptor type Ab
- Symbol
- ednrab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable endothelin receptor activity. Acts upstream of or within cardioblast migration to the midline involved in heart rudiment formation; cartilage development; and embryonic viscerocranium morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in cranial ganglion; gill; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85942 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Endothelin receptor A | Endothelin receptor family | GPCR, rhodopsin-like, 7TM | G-protein coupled endothelin receptor | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P7F8 | InterPro | 408 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ednrab-201
(1)
|
Ensembl | 1,649 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-656F9 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:85942 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:175038 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212930 (1) | 1712 nt | ||
| Genomic | GenBank:CU656041 (1) | 42261 nt | ||
| Polypeptide | UniProtKB:A0A8M1P7F8 (1) | 408 aa |
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gordon, C.T., Weaver, K.N., Zechi-Ceide, R.M., Madsen, E.C., Tavares, A.L., Oufadem, M., Kurihara, Y., Adameyko, I., Picard, A., Breton, S., Pierrot, S., Biosse-Duplan, M., Voisin, N., Masson, C., Bole-Feysot, C., Nitschké, P., Delrue, M.A., Lacombe, D., Guion-Almeida, M.L., Moura, P.P., Garib, D.G., Munnich, A., Ernfors, P., Hufnagel, R.B., Hopkin, R.J., Kurihara, H., Saal, H.M., Weaver, D.D., Katsanis, N., Lyonnet, S., Golzio, C., Clouthier, D.E., Amiel, J. (2015) Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. American journal of human genetics. 96:519-31
- Alexander, C., Piloto, S., Le Pabic, P., Schilling, T.F. (2014) Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genetics. 10:e1004479
- Guh, Y.J., Tseng, Y.C., Yang, C.Y., and Hwang, P.P. (2014) Endothelin-1 regulates H+-ATPase-dependent transepithelial H+ secretion in zebrafish. Endocrinology. 155(5):1728-37
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