Gene
rad51
- ID
- ZDB-GENE-040426-2286
- Name
- RAD51 recombinase
- Symbol
- rad51 Nomenclature History
- Previous Names
-
- wu:fb38e12
- zgc:77754
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; response to cadmium ion; and response to methylmercury. Predicted to be located in chromosome and nucleus. Predicted to be active in condensed nuclear chromosome. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77754 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kh54 | Allele with one deletion | Exon 4 | Frameshift | CRISPR | |
| kh55 | Allele with one deletion | Exon 4 | Inframe Deletion | CRISPR | |
| la010614Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021690Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23805 | Allele with one point mutation | Exon 7 | Premature Stop | ENU | |
| sa25145 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rad51 | Shin et al., 2021 | |
| MO1-rad51 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| Fanconi anemia complementation group R | Alliance | Fanconi anemia, complementation group R | 617244 |
| mirror movements 2 | Alliance | Mirror movements 2 | 614508 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | rad51sa23805/sa23805 | standard conditions | Botthof et al., 2017 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020587 | DNA recombination and repair protein RecA, monomer-monomer interface |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR011941 | DNA recombination/repair protein Rad51 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA recombination and repair protein RecA, monomer-monomer interface | DNA recombination/repair protein Rad51 | DNA repair Rad51/transcription factor NusA, alpha-helical | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TYR1 | InterPro | 340 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-199I12 | ZFIN Curated Data | |
| Encodes | EST | fb38e12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77754 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213206 (1) | 1380 nt | ||
| Genomic | GenBank:CR855367 (1) | 205562 nt | ||
| Polypeptide | UniProtKB:Q5TYR1 (1) | 340 aa |
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Chatterjee, A., Maity, S., Banerjee, S., Dutta, S., Adhikari, M., Guchhait, R., Biswas, C., De, S., Pramanick, K. (2022) Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis. The Science of the total environment. 830:154796
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2022) Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. International Journal of Molecular Sciences. 23(5):
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
- Eid, J.I., Al-Tuwaijri, M.M., Mohanty, S., Das, B. (2021) Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes. Heliyon. 7:e06003
- Falfushynska, H., Horyn, O., Osypenko, I., Rzymski, P., Wejnerowski, Ł., Dziuba, M.K., Sokolova, I.M. (2021) Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 194:116923
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Yang, L., Webb, S.E., Jin, N., Lee, H.M., Chan, T.F., Xu, G., Chan, J.C.N., Miller, A.L., Ma, R.C.W. (2021) Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Journal of diabetes investigation. 12(5):710-727
- Hu, J., Liu, J., Li, J., Lv, X., Yu, L., Wu, K., Yang, Y. (2020) Metal contamination, bioaccumulation, ROS generation, and epigenotoxicity influences on zebrafish exposed to river water polluted by mining activities. Journal of hazardous materials. 405:124150
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