Gene

uhrf1

ID
ZDB-GENE-040426-2039
Name
ubiquitin-like with PHD and ring finger domains 1
Symbol
uhrf1 Nomenclature History
Previous Names
  • fb97f09
  • NP95 (1)
  • unm b1115
  • unm_b1115
  • wu:fb97f09
  • zgc:63539
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable several functions, including hemi-methylated DNA-binding activity; histone H3K9me2/3 reader activity; and histone binding activity. Acts upstream of or within several processes, including intestinal epithelial structure maintenance; lens development in camera-type eye; and negative regulation of gene expression via chromosomal CpG island methylation. Is active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and presumptive neural retina. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
41 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
b1115Allele with one point mutationExon 16NonsynonymousENU
hi272TgTransgenic insertionIntron 1UnknownDNA
hi3020TgTransgenic insertionIntron 1UnknownDNA
pd1092Allele with one point mutationDonor Splice Site of Exon 5Splice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-uhrf1N/A (4)
MO2-uhrf1N/AHuang et al., 2013
MO3-uhrf1N/AKent et al., 2016
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Human Disease
Associated With uhrf1 Human Ortholog
No data available
Associated With uhrf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
Domain IPR000626 Ubiquitin-like domain
Domain IPR001841 Zinc finger, RING-type
Domain IPR001965 Zinc finger, PHD-type
1 - 5 of 15 Show all
Domain Details Per Protein
Protein Additional Resources Length E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain PUA-like superfamily SRA-YDG SRA-YDG superfamily Ubiquitin-like domain Ubiquitin-like domain superfamily UHRF1/2-like UHRF1, tandem tudor domain Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, PHD-type, conserved site Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site
UniProtKB:E7EZF3 InterPro PDB 776
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA uhrf1-201 (1) Ensembl 5,079 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-uhrf1 polyclonal Rabbit
  • IHC
1
Ab1-uhrf1 polyclonal Rabbit
  • WB
2
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-124A3ZFIN Curated Data
EncodesESTfb97f09
EncodescDNAMGC:63539ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanUHRF119
Amino acid sequence comparison (3)
MouseUhrf117
Amino acid sequence comparison (3)
Citations
1 - 10 of 31
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