Gene
uhrf1
- ID
- ZDB-GENE-040426-2039
- Name
- ubiquitin-like with PHD and ring finger domains 1
- Symbol
- uhrf1 Nomenclature History
- Previous Names
-
- fb97f09
- NP95 (1)
- unm b1115
- unm_b1115
- wu:fb97f09
- zgc:63539
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including hemi-methylated DNA-binding activity; histone H3K9me2/3 reader activity; and histone binding activity. Acts upstream of or within several processes, including intestinal epithelial structure maintenance; lens development in camera-type eye; and negative regulation of gene expression via chromosomal CpG island methylation. Is active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and presumptive neural retina. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63539 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 41 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-uhrf1 | N/A | (4) |
| MO2-uhrf1 | N/A | Huang et al., 2013 |
| MO3-uhrf1 | N/A | Kent et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain | PUA-like superfamily | SRA-YDG | SRA-YDG superfamily | Ubiquitin-like domain | Ubiquitin-like domain superfamily | UHRF1/2-like | UHRF1, tandem tudor domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EZF3 | InterPro PDB | 776 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-124A3 | ZFIN Curated Data | |
| Encodes | EST | fb97f09 | ||
| Encodes | cDNA | MGC:63539 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213077 (1) | 5099 nt | ||
| Genomic | GenBank:BX927276 (1) | 166844 nt | ||
| Polypeptide | UniProtKB:E7EZF3 (1) | 776 aa |
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Portolés, I., Ribera, J., Fernandez-Galán, E., Lecue, E., Casals, G., Melgar-Lesmes, P., Fernández-Varo, G., Boix, L., Sanduzzi, M., Aishwarya, V., Reig, M., Jiménez, W., Morales-Ruiz, M. (2024) Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. International Journal of Molecular Sciences. 25(7):
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Duan, X.Y., Ma, R.J., Hsiao, C.D., Jiang, Z.Z., Zhang, L.Y., Zhang, Y., Liu, K.C. (2021) Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 19:750-757
- El Fersioui, Y., Pinton, G., Allaman-Pillet, N., Schorderet, D.F. (2021) Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish. PLoS One. 16:e0245239
- Madakashira, B.P., Zhang, C., Macchi, F., Magnani, E., Sadler, K.C. (2021) Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Genes. 12(7):
- Magnani, E., Macchi, F., Madakashira, B.P., Zhang, C., Alaydaroos, F., Sadler, K.C. (2021) uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements. Frontiers in immunology. 12:627926
- Can, H., Chanumolu, S.K., Gonzalez-Muñoz, E., Prukudom, S., Otu, H.H., Cibelli, J.B. (2020) Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. BMC Genomics. 21:471
- Ganz, J., Melancon, E., Wilson, C., Amores, A., Batzel, P., Strader, M., Braasch, I., Diba, P., Kuhlman, J.A., Postlethwait, J.H., Eisen, J.S. (2019) Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development. Developmental Biology. 455:473-484
- Jiang, Y., Li, J., Ren, F., Ji, C., Aniagu, S., Chen, T. (2019) PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Environmental pollution (Barking, Essex : 1987). 255:113331
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