Gene
uhrf1
- ID
- ZDB-GENE-040426-2039
- Name
- ubiquitin-like with PHD and ring finger domains 1
- Symbol
- uhrf1 Nomenclature History
- Previous Names
-
- fb97f09
- NP95 (1)
- unm b1115
- unm_b1115
- wu:fb97f09
- zgc:63539
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including hemi-methylated DNA-binding activity; histone H3K9me2/3 reader activity; and histone binding activity. Acts upstream of or within several processes, including intestinal epithelial structure maintenance; lens development in camera-type eye; and negative regulation of gene expression via chromosomal CpG island methylation. Is active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and presumptive neural retina. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63539 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 41 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000626 | Ubiquitin-like domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003105 | SRA-YDG |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR021991 | UHRF1, tandem tudor domain |
| Domain | IPR047406 | E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain |
| Family | IPR045134 | UHRF1/2-like |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR015947 | PUA-like superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036987 | SRA-YDG superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain | PUA-like superfamily | SRA-YDG | SRA-YDG superfamily | Ubiquitin-like domain | Ubiquitin-like domain superfamily | UHRF1/2-like | UHRF1, tandem tudor domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EZF3 | InterPro PDB | 776 |
Interactions and Pathways
No data available
Plasmids
No data available