Gene

rlbp1b

ID
ZDB-GENE-040426-1870
Name
retinaldehyde binding protein 1b
Symbol
rlbp1b Nomenclature History
Previous Names
  • cralbpa (1)
  • rlbp1
  • rlbp1a (1)
  • zgc:77766
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable phosphatidylinositol bisphosphate binding activity. Acts upstream of or within optokinetic behavior. Is expressed in optic vesicle; otic vesicle; pericardial region; pronephric duct; and sensory system. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to human RLBP1 (retinaldehyde binding protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la014690TgTransgenic insertionUnknownUnknownDNA
sa3301Allele with one point mutationUnknownPremature StopENU
ucd14Allele with one delinsExon 3UnknownCRISPR
zh9Allele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With rlbp1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bothnia retinal dystrophy Alliance Bothnia retinal dystrophy 607475
fundus albipunctatus Alliance Fundus albipunctatus 136880
fundus albipunctatus Alliance Retinitis punctata albescens 136880
Newfoundland cone-rod dystrophy Alliance Newfoundland rod-cone dystrophy 607476
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Associated With rlbp1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001251 CRAL-TRIO lipid binding domain
Domain IPR011074 CRAL/TRIO, N-terminal domain
Homologous_superfamily IPR036273 CRAL/TRIO, N-terminal domain superfamily
Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length CRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily CRAL/TRIO, N-terminal domain CRAL/TRIO, N-terminal domain superfamily
UniProtKB:Q6P027 InterPro 307
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rlbp1b-201 (1) Ensembl 1,653 nt
mRNA rlbp1b-202 (1) Ensembl 1,520 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rlbp polyclonal Rabbit
  • IHC
  • WB
4
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEYP-19H3ZFIN Curated Data
EncodesESTIMAGE:6897952Thisse et al., 2004
EncodescDNAMGC:77766ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanRLBP115
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
MouseRlbp17
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
Fruit flyCralbp3L
Amino acid sequence comparison (1)
Citations
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