Gene
tfap2e
- ID
- ZDB-GENE-040426-1455
- Name
- transcription factor AP-2 epsilon
- Symbol
- tfap2e Nomenclature History
- Previous Names
-
- zgc:65882
- zgc:77338
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within melanocyte differentiation. Predicted to be active in nucleus. Is expressed in melanoblast; nervous system; and neural crest cell. Orthologous to human TFAP2E (transcription factor AP-2 epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor AP-2 | Transcription factor AP-2, C-terminal |
|---|---|---|---|---|
| UniProtKB:Q6P0E7 | InterPro | 423 | ||
| UniProtKB:A0A8M9PAV2 | InterPro | 432 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tfap2e-201
(1)
|
Ensembl | 1,400 nt | ||
| mRNA |
tfap2e-202
(1)
|
Ensembl | 2,865 nt | ||
| mRNA |
tfap2e-203
(1)
|
Ensembl | 3,548 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tfap2e | polyclonal | IgG | Rabbit |
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-317L21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65882 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77338 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200821 (1) | 1706 nt | ||
| Genomic | GenBank:FO744846 (1) | 42716 nt | ||
| Polypeptide | UniProtKB:A0A8M9PAV2 (1) | 432 aa |
- Kalanithy, J.C., Mingardo, E., Stegmann, J.D., Dhakar, R., Dakal, T.C., Rosenfeld, J.A., Tan, W.H., Coury, S.A., Woerner, A.C., Sebastian, J., Levy, P.A., Fleming, L.R., Waffenschmidt, L., Lindenberg, T.T., Yilmaz, Ö., Channab, K., Babra, B.K., Christ, A., Eiberger, B., Hölzel, S., Vidic, C., Häberlein, F., Ishorst, N., Rodriguez-Gatica, J.E., Pezeshkpoor, B., Kupczyk, P.A., Vanakker, O.M., Loddo, S., Novelli, A., Dentici, M.L., Becker, A., Thiele, H., Posey, J.E., Lupski, J.R., Hilger, A.C., Reutter, H.M., Merz, W.M., Dworschak, G.C., Odermatt, B. (2024) TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies. Journal of Medical Genetics. :
- Kenny, C., Dilshat, R., Seberg, H.E., Van Otterloo, E., Bonde, G., Helverson, A., Franke, C.M., Steingrímsson, E., Cornell, R.A. (2022) TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes. PLoS Genetics. 18:e1010207
- Campbell, N.R., Rao, A., Hunter, M.V., Sznurkowska, M.K., Briker, L., Zhang, M., Baron, M., Heilmann, S., Deforet, M., Kenny, C., Ferretti, L.P., Huang, T.H., Perlee, S., Garg, M., Nsengimana, J., Saini, M., Montal, E., Tagore, M., Newton-Bishop, J., Middleton, M.R., Corrie, P., Adams, D.J., Rabbie, R., Aceto, N., Levesque, M.P., Cornell, R.A., Yanai, I., Xavier, J.B., White, R.M. (2021) Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Developmental Cell. 56(20):2808-2825.e10
- Wang, H., Meng, Z., Liu, F., Zhou, L., Su, M., Meng, Y., Zhang, S., Liao, X., Cao, Z., Lu, H. (2019) Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos. Chemosphere. 238:124753
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Seberg, H.E., Van Otterloo, E., Loftus, S.K., Liu, H., Bonde, G., Sompallae, R., Gildea, D.E., Santana, J.F., Manak, J.R., Pavan, W.J., Williams, T., Cornell, R.A. (2017) TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genetics. 13:e1006636
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Van Otterloo, E., Li, W., Garnett, A., Cattell, M., Medeiros, D.M., and Cornell, R.A. (2012) Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest. Development (Cambridge, England). 139(4):720-730
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
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