Gene
cct4
- ID
- ZDB-GENE-040426-1421
- Name
- chaperonin containing TCP1, subunit 4 (delta)
- Symbol
- cct4 Nomenclature History
- Previous Names
-
- zgc:65789
- zgc:77192 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable unfolded protein binding activity. Acts upstream of or within eye morphogenesis and response to hypoxia. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including head; immature eye; midbrain; muscle; and pectoral fin bud. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65789 (1 image)
- IMAGE:6907982 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cct4 | (2) | |
| CRISPR2-cct4 | Sun et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002194 | Chaperonin TCP-1, conserved site |
| Family | IPR002423 | Chaperonin Cpn60/GroEL/TCP-1 family |
| Family | IPR012717 | T-complex protein 1, delta subunit |
| Family | IPR017998 | Chaperone tailless complex polypeptide 1 (TCP-1) |
| Family | IPR053374 | TCP-1 chaperonin-containing T-complex |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Chaperone tailless complex polypeptide 1 (TCP-1) | Chaperonin Cpn60/GroEL/TCP-1 family | Chaperonin TCP-1, conserved site | GroEL-like apical domain superfamily | GroEL-like equatorial domain superfamily | T-complex protein 1, delta subunit | TCP-1 chaperonin-containing T-complex | TCP-1-like chaperonin intermediate domain superfamily | Thermosome subunit alpha |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PH46 | InterPro | 533 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-237G6 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-663F11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6907982 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:65789 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77192 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200583 (1) | 1940 nt | ||
| Genomic | GenBank:CU693443 (1) | 43828 nt | ||
| Polypeptide | UniProtKB:Q6PH46 (1) | 533 aa |
- Berger, S., D Currie, P., Berger, J. (2023) The Role of TRiC-enhanced Actin Folding in Leber Congenital Amaurosis. Journal of Ophthalmic & Vision Research. 18:606760-67
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Zhang, X., Li, X., Li, R., Zhang, Y., Li, Y., Li, S. (2019) Transcriptomic profile of early zebrafish PGCs by single cell sequencing. PLoS One. 14:e0220364
- Berger, J., Berger, S., Li, M., Jacoby, A.S., Arner, A., Bavi, N., Stewart, A.G., Currie, P.D. (2018) In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly. Cell Reports. 22:313-322
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lyche, J.L., Nourizadeh-Lillabadi, R., Karlsson, C., Stavik, B., Berg, V., Skåre, J.U., Alestrøm, P., and Ropstad, E. (2011) Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquatic toxicology (Amsterdam, Netherlands). 102(3-4):197-204
- Lyche, J.L., Nourizadeh-Lillabadi, R., Almaas, C., Stavik, B., Berg, V., Skåre, J.U., Alestrøm, P., and Ropstad, E. (2010) Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Journal of toxicology and environmental health. Part A. 73(15):1032-1057
- van der Meer, D.L., van den Thillart, G.E., Witte, F., de Bakker, M.A., Besser, J., Richardson, M.K., Spaink, H.P., Leito, J.T., and Bagowski, C.P. (2005) Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 286(5):R1512-1519
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