Gene

irf6

ID
ZDB-GENE-040426-1137
Name
interferon regulatory factor 6
Symbol
irf6 Nomenclature History
Previous Names
  • zgc:63500 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epidermis development. Acts upstream of or within embryonic neurocranium morphogenesis; epithelium development; and hard palate morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; digestive system; ethmoid cartilage; oral region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; cleft palate; orofacial cleft 6; and popliteal pterygium syndrome. Orthologous to human IRF6 (interferon regulatory factor 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa11387Allele with one point mutationUnknownPremature StopENU
sa19276Allele with one point mutationUnknownPremature StopENU
zf2064Allele with one deletionExon 6Frameshift, Premature StopCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With irf6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 6 Alliance {Orofacial cleft 6} 608864
popliteal pterygium syndrome Alliance Popliteal pterygium syndrome 1 119500
Van der Woude syndrome Alliance van der Woude syndrome 1 119300
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Associated With irf6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor, DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Interferon regulatory factor-3 Interferon regulatory factor, conserved site Interferon regulatory factor, DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6PGZ7 InterPro 492
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA irf6-201 (1) Ensembl 831 nt
mRNA irf6-202 (1) Ensembl 2,746 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-irf6 polyclonal Rabbit
  • IHC
1
Ab2-irf6 polyclonal Rabbit
  • IHC
1
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Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(sox10:irf6_R84C,myl7:EGFP)
  • Danio rerio
1 (3)
Tg(sox10:irf6_R84H,myl7:EGFP))
  • Danio rerio
1 (3)
Tg(sox10:irf6_R84K,myl7:EGFP)
  • Danio rerio
1 (3)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-103A14ZFIN Curated Data
EncodescDNAMGC:63500ZFIN Curated Data
Has ArtifactcDNAMGC:165439
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIRF61
Phylogenetic tree (2)
Functional complementation (1)
Amino acid sequence comparison (5)
MouseIrf61
Amino acid sequence comparison (4)
Phylogenetic tree (2)
Citations
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