Gene
irf6
- ID
- ZDB-GENE-040426-1137
- Name
- interferon regulatory factor 6
- Symbol
- irf6 Nomenclature History
- Previous Names
-
- zgc:63500 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epidermis development. Acts upstream of or within embryonic neurocranium morphogenesis; epithelium development; and hard palate morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; digestive system; ethmoid cartilage; oral region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; cleft palate; orofacial cleft 6; and popliteal pterygium syndrome. Orthologous to human IRF6 (interferon regulatory factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irf6 | (4) | |
| MO1-irf6 | N/A | Sabel et al., 2009 |
| MO2-irf6 | N/A | (2) |
| MO3-irf6 | N/A | Sabel et al., 2009 |
| MO4-irf6 | N/A | Sabel et al., 2009 |
| MO5-irf6 | N/A | Sabel et al., 2009 |
| MO6-irf6 | N/A | Manesia et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| orofacial cleft 6 | Alliance | {Orofacial cleft 6} | 608864 |
| popliteal pterygium syndrome | Alliance | Popliteal pterygium syndrome 1 | 119500 |
| Van der Woude syndrome | Alliance | van der Woude syndrome 1 | 119300 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PGZ7 | InterPro | 492 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103A14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63500 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:165439 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200598 (1) | 2752 nt | ||
| Genomic | GenBank:CU570769 (1) | 135885 nt | ||
| Polypeptide | UniProtKB:Q6PGZ7 (1) | 492 aa |
- Ye, J., Lu, L., Rui, X.H., Ren, M.D., Tu, F., Shang, Z.B., Liu, J. (2025) Zebrafish as a model for investigating Klebsiella pneumoniae-driven lung injury and therapeutic targets. Experimental Lung Research. 51:112211-22
- Ishorst, N., Hölzel, S., Greve, C., Yilmaz, Ö., Lindenberg, T., Lambertz, J., Drichel, D., Zametica, B., Mingardo, E., Kalanithy, J.C., Channab, K., Kibris, D., Henne, S., Degenhardt, F., Siewert, A., Dixon, M., Kruse, T., Ongkosuwito, E., Girisha, K.M., Pande, S., Nowak, S., Hagelueken, G., Geyer, M., Carels, C., van Rooij, I.A.L.M., Ludwig, K.U., Odermatt, B., Mangold, E. (2024) Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. European journal of human genetics : EJHG. :
- Murali, H., Wang, P., Liao, E.C., Wang, K. (2024) Genetic variant classification by predicted protein structure: A case study on IRF6. Computational and structural biotechnology journal. 23:892904892-904
- An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Zhang, M., Zhang, J., Zhao, H., Ievlev, V., Zhong, W., Huang, W., Cornell, R.A., Lin, J., Chen, F. (2020) Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family. Frontiers in genetics. 11:562
- Zhao, X., Gong, X.Y., Li, Y.L., Dan, C., Gui, J.F., Zhang, Y.B. (2020) Characterization of DNA Binding and Nuclear Retention Identifies Zebrafish IRF11 as a Positive Regulator of IFN Antiviral Response. Journal of immunology (Baltimore, Md. : 1950). 205(1):237-250
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
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