Gene
itga9
- ID
- ZDB-GENE-040426-1129
- Name
- integrin, alpha 9
- Symbol
- itga9 Nomenclature History
- Previous Names
-
- zgc:63474
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in membrane. Predicted to be part of integrin alpha9-beta1 complex. Predicted to be active in cell surface. Is expressed in several structures, including cardiovascular system; epidermis; fin bud; pigment cell; and trunk. Human ortholog(s) of this gene implicated in cerebral infarction; hypertension; and pancreatic cancer. Orthologous to human ITGA9 (integrin subunit alpha 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63474 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
Family | IPR000413 | Integrin alpha chain |
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Domain Details Per Protein
Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QFA5 | InterPro | 707 | |||||||||
UniProtKB:F1Q8T4 | InterPro | 1032 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-160D11 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-174D6 | ZFIN Curated Data | |
Encodes | cDNA | MGC:63474 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001324498 (1) | 4078 nt | ||
Genomic | GenBank:AL772263 (2) | 153222 nt | ||
Polypeptide | UniProtKB:F1Q8T4 (1) | 1032 aa |
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Gunawan, F., Gentile, A., Fukuda, R., Tsedeke, A.T., Jiménez-Amilburu, V., Ramadass, R., Iida, A., Sehara-Fujisawa, A., Stainier, D.Y.R. (2019) Focal adhesions are essential to drive zebrafish heart valve morphogenesis. The Journal of cell biology. 218(3):1039-1054
- Shin, M., Nozaki, T., Idrizi, F., Isogai, S., Ogasawara, K., Ishida, K., Yuge, S., Roscoe, B., Wolfe, S.A., Fukuhara, S., Mochizuki, N., Deguchi, T., Lawson, N.D. (2019) Valves Are a Conserved Feature of the Zebrafish Lymphatic System. Developmental Cell. 51(3):374-386.e5
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Zou, Q., Gang, K., Yang, Q., Liu, X., Tang, X., Lu, H., He, J., Luo, L. (2018) The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish. The Journal of biological chemistry. 293(31):11971-11983
- Kärpanen, T., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., Schulte-Merker, S. (2017) An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circulation research. 120(8):1263-1275
- Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., Horsfield, J.A. (2015) A neural crest origin for cohesinopathy heart defects. Human molecular genetics. 24(24):7005-16
- Yang, Y., Enis, D., Zheng, H., Chia, S., Yang, J., Chen, M., Dhillon, V., Papayannapoulou, T., Kahn, M.L. (2015) Cell Adhesion Mediated by VCAM-ITGa9 Interactions Enables Lymphatic Development. Arterioscler. Thromb. Vasc. Biol.. 35(5):1179-89
- Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
- Lien, Y.C., Ou, T.Y., Lin, Y.T., Kuo, P.C., and Lin, H.J. (2013) Duplication and Diversification of the Spermidine/Spermine N(1)-acetyltransferase 1 Genes in Zebrafish. PLoS One. 8(1):e54017
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