Gene
chuk
- ID
- ZDB-GENE-040426-1069
- Name
- component of inhibitor of nuclear factor kappa B kinase complex
- Symbol
- chuk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to contribute to IkappaB kinase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; negative regulation of canonical NF-kappaB signal transduction; and somite specification. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56539 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Fukazawa et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018485Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p20ad | Allele with one point mutation | Unknown | Missense | ENU | |
| sa35487 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35488 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fetal encasement syndrome | Alliance | ?Cocoon syndrome | 613630 |
| ?Popliteal pterygium syndrome, Bartsocas-Papas type 2 | 619339 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR022007 | I-kappa-kinase-beta NEMO binding domain |
| Domain | IPR041185 | IKBKB, scaffold dimerization domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | I-kappa-kinase-beta NEMO binding domain | IKBKB, scaffold dimerization domain | IKBKB, scaffold dimerization domain superfamily | Inhibitor of nuclear factor kappa-B kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q4G3H4 | InterPro | 758 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51A16 | Correa et al., 2005 | |
| Contained in | BAC | DKEY-252G6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56539 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200317 (1) | 3321 nt | ||
| Genomic | GenBank:BX530079 (1) | 166397 nt | ||
| Polypeptide | UniProtKB:Q4G3H4 (1) | 758 aa |
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Chen, B., Li, C., Yao, J., Shi, L., Liu, W., Wang, F., Huo, S., Zhang, Y., Lu, Y., Ashraf, U., Ye, J., Liu, X. (2020) Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-κB. Journal of immunology (Baltimore, Md. : 1950). 204(7):1881-1891
- Qin, J., Ru, S., Wang, W., Hao, L., Ru, Y., Wang, J., Zhang, X. (2020) Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Environmental pollution (Barking, Essex : 1987). 263:114535
- Nguyen, T., Payan, B., Zambrano, A., Du, Y., Bondesson, M., Mohan, C. (2019) Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. Journal of inflammation research. 12:231-239
- Petridou, N.I., Grigolon, S., Salbreux, G., Hannezo, E., Heisenberg, C.P. (2018) Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature cell biology. 21(2):169-178
- Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R.I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J.D., Klaeylé, L., Langa, X., Beckmann, C.C.A., Wlodarski, M.W., Müller, P., Van Essen, D., Rambold, A., Kapp, F.G., Mione, M., Buescher, J.M., Pearce, E.L., Polyzos, A., Trompouki, E. (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications. 9:3090
- Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334
- Lisse, T.S., Rieger, S. (2017) IKKα regulates human keratinocyte migration through surveillance of the redox environment. Journal of Cell Science. 130:975-988
- Morita, H., Grigolon, S., Bock, M., Krens, S.F., Salbreux, G., Heisenberg, C.P. (2017) The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation. Developmental Cell. 40(4):354-366.e4
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