Gene
tlr3
- ID
- ZDB-GENE-040219-7
- Name
- toll-like receptor 3
- Symbol
- tlr3 Nomenclature History
- Previous Names
-
- zgc:123006
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium and response to virus. Predicted to be located in early endosome; endoplasmic reticulum membrane; and endosome membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; liver disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu558 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Graber et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR041015 | Toll-like receptor 3 trans-membrane domain |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor 3 trans-membrane domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q32PW5 | InterPro | 903 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-11A2 | ZFIN Curated Data | |
| Encodes | EST | eu558 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:123006 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013269 (1) | 3161 nt | ||
| Genomic | GenBank:CR774194 (2) | 160120 nt | ||
| Polypeptide | UniProtKB:Q32PW5 (1) | 903 aa |
- Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
- Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629
- Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
- Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Deng, Z., Hou, K., Valencak, T.G., Luo, X.M., Liu, J., Wang, H. (2022) AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish. Microbiology spectrum. 10(4):e0061022
- Graber, M., Nägele, F., Röhrs, B.T., Hirsch, J., Pölzl, L., Moriggl, B., Mayr, A., Troger, F., Kirchmair, E., Wagner, J.F., Nowosielski, M., Mayer, L., Voelkl, J., Tancevski, I., Meyer, D., Grimm, M., Knoflach, M., Holfeld, J., Gollmann-Tepeköylü, C. (2022) Prevention of Oxidative Damage in Spinal Cord Ischemia Upon Aortic Surgery: First-In-Human Results of Shock Wave Therapy Prove Safety and Feasibility. Journal of the American Heart Association. 11(20):e026076
- Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
- Shan, S., Liu, R., Feng, H., Meng, F., Aizaz, M., Yang, G. (2021) Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response. Veterinary research. 52:88
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