Gene
pxna
- ID
- ZDB-GENE-040105-1
- Name
- paxillin a
- Symbol
- pxna Nomenclature History
- Previous Names
-
- pxn
- wu:fw71f12
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including heart contraction; skeletal muscle tissue development; and somite development. Predicted to be located in cell cortex; cytoskeleton; and focal adhesion. Is expressed in several structures, including Kupffer's vesicle; eye; myotome; notochord posterior region; and somite. Orthologous to human PXN (paxillin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa30479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38178 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sny6300 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sny6400 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sny6500 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 5 of 5
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-pxna | Jacob et al., 2017 | |
MO1-pxna | N/A | Jacob et al., 2017 |
MO2-pxna | N/A | Hirth et al., 2016 |
MO3-pxna | N/A | Hirth et al., 2016 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Paxillin, Lim domain 2 | Paxillin, Lim domain 4 | Paxillin/TGFB1I1, LIM domain 1 | Zinc finger, LIM-type |
---|---|---|---|---|---|---|
UniProtKB:Q6R3L1 | InterPro | 533 |
1 - 1 of 1
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-pxn | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
10 |
1 - 1 of 1
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(actb2:pxn-EGFP) |
|
| 1 | (9) | |
Tg(hsp70l:pxna-EGFP) |
|
| 1 | (2) | |
Tg(mpeg1.1:pxna-EGFP) |
|
| 1 | Xue et al., 2023 | |
Tg(mpeg1.1:pxna_Y95E-EGFP) |
|
| 1 | Xue et al., 2023 | |
Tg(mpeg1.1:pxna_Y95F-EGFP) |
|
| 1 | Xue et al., 2023 |
1 - 5 of 5
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-49H18 | ZFIN Curated Data | |
Encodes | EST | fw71f12 | ||
Encodes | EST | IMAGE:5915845 |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201588 (1) | 2659 nt | ||
Genomic | GenBank:BX950216 (1) | 188648 nt | ||
Polypeptide | UniProtKB:Q6R3L1 (1) | 533 aa |
- Xue, Q., Varady, S.R.S., Waddell, T.Q.A., Roman, M.R., Carrington, J., Roh-Johnson, M. (2023) Lack of Paxillin phosphorylation promotes single-cell migration in vivo. The Journal of cell biology. 222(3):
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
- Bailey, E.C., Alrowaished, S.S., Kilroy, E.A., Crooks, E.S., Drinkert, D.M., Karunasiri, C.M., Belanger, J.J., Khalil, A., Kelley, J.B., Henry, C.A. (2019) NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy. Skeletal muscle. 9:21
- Uroz, M., Garcia-Puig, A., Tekeli, I., Elosegui-Artola, A., Abenza, J.F., Marín-Llauradó, A., Pujals, S., Conte, V., Albertazzi, L., Roca-Cusachs, P., Raya, Á., Trepat, X. (2019) Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. Nature Materials. 18(9):1015-1023
- Coffey, E.C., Pasquarella, M.E., Goody, M.F., Henry, C.A. (2018) Ethanol Exposure Causes Muscle Degeneration in Zebrafish. Journal of developmental biology. 6(1)
- Jacob, A.E., Amack, J.D., Turner, C.E. (2017) Paxillin Genes and Actomyosin Contractility Regulate Myotome Morphogenesis in Zebrafish. Developmental Biology. 425(1):70-84
- Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S. (2016) Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS One. 11:e0150323
- Jacob, A.E., Turner, C.E., Amack, J.D. (2016) Evolution and Expression of Paxillin Genes in Teleost Fish. PLoS One. 11:e0165266
- Subramanian, A., Schilling, T.F. (2014) Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. eLIFE. 6(8):e02372
- Goody, M.F., Kelly, M.W., Reynolds, C.J., Khalil, A., Crawford, B.D., and Henry, C.A. (2012) NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. PLoS Biology. 10(10):e1001409
1 - 10 of 15
Show