Gene
ahcy
- ID
- ZDB-GENE-031219-6
- Name
- adenosylhomocysteinase
- Symbol
- ahcy Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable adenosylhomocysteinase activity. Acts upstream of or within S-adenosylmethionine cycle. Predicted to be active in cytosol. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Used to study metabolic dysfunction-associated steatotic liver disease and steatotic liver disease. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1079 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025635Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p14nb | Allele with one point mutation | Exon 8 | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ahcy | N/A | Matthews et al., 2009 |
| MO2-ahcy | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase | Alliance | Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase | 613752 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | ahcyp14nb/p14nb | standard conditions | (2) |
| metabolic dysfunction-associated steatotic liver disease | ahcyp14nb/+ | control | Sapp et al., 2014 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020082 | S-adenosyl-L-homocysteine hydrolase, conserved site |
| Domain | IPR015878 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
| Family | IPR000043 | Adenosylhomocysteinase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR042172 | Adenosylhomocysteinase-like superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adenosylhomocysteinase-like | Adenosylhomocysteinase-like superfamily | NAD(P)-binding domain superfamily | S-adenosyl-L-homocysteine hydrolase, conserved site | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q803T5 | InterPro | 433 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16N21 | ZFIN Curated Data | |
| Encodes | EST | cb1079 | Thisse et al., 2001 | |
| Encodes | EST | fj67b02 | ZFIN Curated Data | |
| Encodes | EST | zeh1173 | ||
| Encodes | EST | zeh1364 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55617 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191701 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199218 (1) | 1940 nt | ||
| Genomic | GenBank:BX629346 (1) | 214213 nt | ||
| Polypeptide | UniProtKB:Q803T5 (1) | 433 aa |
- Fustin, J.M., Ye, S., Rakers, C., Kaneko, K., Fukumoto, K., Yamano, M., Versteven, M., Grünewald, E., Cargill, S.J., Tamai, T.K., Xu, Y., Jabbur, M.L., Kojima, R., Lamberti, M.L., Yoshioka-Kobayashi, K., Whitmore, D., Tammam, S., Howell, P.L., Kageyama, R., Matsuo, T., Stanewsky, R., Golombek, D.A., Johnson, C.H., Kakeya, H., van Ooijen, G., Okamura, H. (2020) Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology. 3:211
- Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cal, L., MegÍas, M., Cerdá-Reverter, J.M., Postlethwait, J.H., Braasch, I., Rotllant, J. (2017) BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):697-708
- Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W. (2016) Cannabinoid receptor signaling regulates liver development and metabolism. Development (Cambridge, England). 143:609-22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
- Sapp, V., Gaffney, L., EauClaire, S.F., Matthews, R.P. (2014) Fructose leads to hepatic steatosis in zebrafish that is reversed by mTOR inhibition. Hepatology (Baltimore, Md.). 60(5):1581-92
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
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