Gene
stm
- ID
- ZDB-GENE-031112-4
- Name
- starmaker
- Symbol
- stm Nomenclature History
- Previous Names
-
- cb885 (1)
- id:ibd5112
- sb:cb148
- sb:cb568
- sb:cb584
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables calcium ion binding activity. Acts upstream of or within detection of gravity; egg coat formation; and inner ear development. Predicted to be located in extracellular region. Is expressed in several structures, including Kupffer's vesicle; anterior axial hypoblast; central nervous system; immature eye; and sensory system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb148 (11 images)
- cb568 (10 images)
- cb584 (24 images)
- cb885 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028054Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15436 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36758 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| umo42 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| szu1 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stm | (2) | |
| CRISPR2-stm | Zebrafish Nomenclature Committee | |
| CRISPR3-stm | Lin et al., 2025 | |
| CRISPR4-stm | Lin et al., 2025 | |
| MO1-stm | N/A | Söllner et al., 2003 |
| MO2-stm | N/A | Söllner et al., 2003 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M2B5U7 | InterPro | 600 |
| UniProtKB:A2VD23 | InterPro | 613 |
| UniProtKB:A0A8M2B5U9 | InterPro | 612 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-80H18 | ZFIN Curated Data | |
| Encodes | EST | cb148 | Thisse et al., 2001 | |
| Encodes | EST | cb568 | Thisse et al., 2001 | |
| Encodes | EST | cb584 | Thisse et al., 2001 | |
| Encodes | EST | cb885 | Thisse et al., 2001 | |
| Encodes | EST | ibd5112 | ||
| Encodes | cDNA | MGC:158193 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198817 (1) | 3197 nt | ||
| Genomic | GenBank:CT574549 (1) | 118955 nt | ||
| Polypeptide | UniProtKB:A2VD23 (1) | 613 aa |
No data available
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Mackowetzky, K., Dicipulo, R., Fox, S.C., Philibert, D.A., Todesco, H., Doshi, J.D., Kawakami, K., Tierney, K., Waskiewicz, A.J. (2022) Retinoic Acid Signaling Regulates Late Stages of Semicircular Canal Morphogenesis and Otolith Maintenance in the Zebrafish Inner Ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(11):1798-1815
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Pachoensuk, T., Fukuyo, T., Rezanujjaman, Md., Wanlada, K., Yamamoto, C., Maeno, A., Mostafizur Rahaman, Md., Hasan Ali, Md., Tokumoto, T. (2021) Zebrafish stm is involved in the development of otoliths and of the fertilization envelope. Reproduction & Fertility. 2(1):7-16
- Kozak, E.L., Palit, S., Miranda-Rodríguez, J.R., Janjic, A., Böttcher, A., Lickert, H., Enard, W., Theis, F.J., López-Schier, H. (2020) Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Current biology : CB. 30(6):1142-1151.e6
- Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
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