Gene
prom1b
- ID
- ZDB-GENE-031003-1
- Name
- prominin 1 b
- Symbol
- prom1b Nomenclature History
- Previous Names
-
- proml2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol binding activity. Acts upstream of or within photoreceptor cell outer segment organization. Located in apical plasma membrane. Is expressed in nervous system; otic vesicle; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146277 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 9 figures from Lu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-prom1b | Sun et al., 2019 | |
CRISPR2-prom1b | Sun et al., 2019 | |
CRISPR3-prom1b | Sun et al., 2019 | |
CRISPR4-prom1b | Sun et al., 2019 | |
TALEN1-prom1b | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cone-rod dystrophy 12 | Alliance | Cone-rod dystrophy 12 | 612657 |
retinal macular dystrophy 2 | Alliance | Macular dystrophy, retinal, 2 | 608051 |
retinitis pigmentosa 41 | Alliance | Retinitis pigmentosa 41 | 612095 |
Stargardt disease | Alliance | Stargardt disease 4 | 603786 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR008795 | Prominin |
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Domain Details Per Protein
Protein | Additional Resources | Length | Prominin |
---|---|---|---|
UniProtKB:A0A8M9QPM2 | InterPro | 877 | |
UniProtKB:A0A8M2BI60 | InterPro | 867 | |
UniProtKB:A0A8M9QPR6 | InterPro | 866 | |
UniProtKB:A0A8M9QH22 | InterPro | 872 | |
UniProtKB:A0A8M9Q036 | InterPro | 874 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
prom1b-201
(1)
|
Ensembl | 3,885 nt | ||
mRNA |
prom1b-202
(1)
|
Ensembl | 546 nt | ||
mRNA |
prom1b-203
(1)
|
Ensembl | 371 nt | ||
mRNA |
prom1b-204
(1)
|
Ensembl | 2,556 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-prom1b | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(h2ax:prom1b-GFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-207I17 | ZFIN Curated Data | |
Contained in | BAC | DKEY-92J12 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7146277 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:73040 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_198071 (1) | 3933 nt | ||
Genomic | GenBank:AL929074 (1) | 165705 nt | ||
Polypeptide | UniProtKB:A0A8M9QBM3 (1) | 883 aa |
- Jászai, J., Thamm, K., Karbanová, J., Janich, P., Fargeas, C.A., Huttner, W.B., Corbeil, D. (2020) Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. The Journal of biological chemistry. 295(18):6007-6022
- Takita, S., Seko, Y. (2020) eys+/- ; lrp5+/- Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle. iScience. 23:101762
- Lu, Z., Hu, X., Reilly, J., Jia, D., Liu, F., Yu, S., Liu, X., Xie, S., Qu, Z., Qin, Y., Huang, Y., Lv, Y., Li, J., Gao, P., Wong, F., Shu, X., Tang, Z., Liu, M. (2019) Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. The Journal of biological chemistry. 294(38):13953-13963
- Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2019) Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evolutionary Biology. 19:38
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Li, Y., Sun, S., Ding, Z., Yang, C., Zhang, G., Jiang, Q., Zou, Y. (2018) Temporal and spatial expression of fgfbp genes in zebrafish. Gene. 659:128-136
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
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