Gene

prom1b

ID
ZDB-GENE-031003-1
Name
prominin 1 b
Symbol
prom1b Nomenclature History
Previous Names
  • proml2
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable cholesterol binding activity. Acts upstream of or within photoreceptor cell outer segment organization. Located in apical plasma membrane. Is expressed in nervous system; otic vesicle; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from Lu et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hzu8Allele with one deletionExon 1UnknownTALEN
sa13905Allele with one point mutationUnknownPremature StopENU
sa32663Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With prom1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 12 Alliance Cone-rod dystrophy 12 612657
retinal macular dystrophy 2 Alliance Macular dystrophy, retinal, 2 608051
retinitis pigmentosa 41 Alliance Retinitis pigmentosa 41 612095
Stargardt disease Alliance Stargardt disease 4 603786
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Associated With prom1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008795 Prominin
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Domain Details Per Protein
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prom1b-201 (1) Ensembl 3,885 nt
mRNA prom1b-202 (1) Ensembl 546 nt
mRNA prom1b-203 (1) Ensembl 371 nt
mRNA prom1b-204 (1) Ensembl 2,556 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-prom1b polyclonal Rabbit
1
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(h2ax:prom1b-GFP)
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-207I17ZFIN Curated Data
Contained inBACDKEY-92J12ZFIN Curated Data
EncodesESTIMAGE:7146277Thisse et al., 2004
EncodescDNAMGC:73040ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPROM14
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseProm15
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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