Gene
trpv1
- ID
- ZDB-GENE-030912-8
- Name
- transient receptor potential cation channel, subfamily V, member 1
- Symbol
- trpv1 Nomenclature History
- Previous Names
-
- TRPV1/2 (1)
- si:dkey-9e15.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity. Involved in flagellated sperm motility. Acts upstream of or within response to heat and thermosensory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelium; keratinocyte; nervous system; pleuroperitoneal region; and sperm. Human ortholog(s) of this gene implicated in migraine. Orthologous to several human genes including TRPV1 (transient receptor potential cation channel subfamily V member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chen et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb141 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| ihb142 | Allele with one delins | Exon 5 | Unknown | CRISPR | |
| ihb143 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa11782 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12465 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33682 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33683 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| xt13 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-trpv1 | (2) | |
| CRISPR2-trpv1 | (2) | |
| CRISPR3-trpv1 | Zebrafish Nomenclature Committee | |
| MO1-trpv1 | N/A | Gau et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Family | IPR008347 | Transient receptor potential cation channel subfamily V member 1-4 |
| Family | IPR024862 | Transient receptor potential cation channel subfamily V |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor potential cation channel subfamily V | Transient receptor potential cation channel subfamily V member 1-4 |
|---|---|---|---|---|---|---|---|
| UniProtKB:B6RTA2 | InterPro | 819 | |||||
| UniProtKB:B0S711 | InterPro | 813 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-trpv1 | polyclonal | IgG | Rabbit |
|
Thermo Fisher Scientific (Lab Vision)
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(slc6a3:trpv1-TagRFP) |
|
| 1 | Sun et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9E15 | ZFIN Curated Data | |
| Encodes | STS | zf37276-283b19.p1k |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126399 (1) | |||
| Genomic | GenBank:BX571977 (1) | 82992 nt | ||
| Polypeptide | UniProtKB:B6RTA2 (1) | 819 aa |
- Son, H.W., Ali, D.W. (2022) Endocannabinoid Receptor Expression in Early Zebrafish Development. Developmental neuroscience. 44(3):142-152
- Jeong, I., Yun, S., Shahapal, A., Cho, E.B., Hwang, S.W., Seong, J.Y., Park, H.C. (2021) FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish. Molecular neurobiology. 58(9):4770-4785
- Knuth, M.M., Stutts, W.L., Ritter, M.M., Garrard, K.P., Kullman, S.W. (2021) Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Journal of Lipid Research. 62:100142
- Takahashi, S., Kurogi, M., Saitoh, O. (2021) The diversity in sensitivity of TRPA1 and TRPV1 of various animals to polyphenols. Biomedical research (Tokyo, Japan). 42:43-51
- Chen, Y., Wang, H., Wang, F., Chen, C., Zhang, P., Song, D., Luo, T., Xu, H., Zeng, X. (2020) Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Theriogenology. 151:41-51
- Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O. (2020) Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Environmental pollution (Barking, Essex : 1987). 264:114710
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- Nam, Y.H., Moon, H.W., Lee, Y.R., Kim, E.Y., Rodriguez, I., Jeong, S.Y., Castañeda, R., Park, J.H., Choung, S.Y., Hong, B.N., Kang, T.H. (2019) Panax ginseng (Korea Red Ginseng) repairs diabetic sensorineural damage through promotion of the nerve growth factor pathway in diabetic zebrafish. Journal of ginseng research. 43:272-281
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2018) Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental pollution (Barking, Essex : 1987). 241:1-8
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
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