Gene
trpv4
- ID
- ZDB-GENE-030912-7
- Name
- transient receptor potential cation channel, subfamily V, member 4
- Symbol
- trpv4 Nomenclature History
- Previous Names
-
- wu:fp52e02
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity. Acts upstream of or within atrioventricular valve development; cellular response to oscillatory fluid shear stress; and response to osmotic stress. Predicted to be located in membrane. Predicted to be active in cilium and plasma membrane. Is expressed in several structures, including brain; head; pectoral fin; pericardial region; and sensory system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa84 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa1671 | Allele with one point mutation | Exon 12 | Premature Stop | ENU | |
| sa15329 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26435 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| whu313 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-trpv4 | (2) | |
| CRISPR2-trpv4 | Yu et al., 2024 | |
| CRISPR3-trpv4 | Apolínová et al., 2024 | |
| CRISPR4-trpv4 | Apolínová et al., 2024 | |
| MO1-trpv4 | N/A | (4) |
| MO2-trpv4 | N/A | (2) |
| MO3-trpv4 | N/A | Liu et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 8 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 8 | 600175 |
| brachyolmia | Alliance | Brachyolmia type 3 | 113500 |
| Charcot-Marie-Tooth disease axonal type 2C | Alliance | Hereditary motor and sensory neuropathy, type IIc | 606071 |
| metatropic dysplasia | Alliance | Metatropic dysplasia | 156530 |
| parastremmatic dwarfism | Alliance | Parastremmatic dwarfism | 168400 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Family | IPR008347 | Transient receptor potential cation channel subfamily V member 1-4 |
| Family | IPR008348 | Transient receptor potential cation channel subfamily V member 4 |
| Family | IPR024862 | Transient receptor potential cation channel subfamily V |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor potential cation channel subfamily V | Transient receptor potential cation channel subfamily V member 1-4 | Transient receptor potential cation channel subfamily V member 4 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCH8 | InterPro | 859 | ||||||
| UniProtKB:Q0PEH1 | InterPro | 841 | ||||||
| UniProtKB:A0A8M2BCE0 | InterPro | 858 | ||||||
| UniProtKB:A0AB32TN82 | InterPro | 828 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234H16 | ZFIN Curated Data | |
| Encodes | EST | fp52e02 | Woods et al., 2005 | |
| Encodes | cDNA | MGC:195087 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001042730 (1) | 2628 nt | ||
| Genomic | GenBank:BX323811 (2) | 204094 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCH8 (1) | 859 aa |
- Apolínová, K., Pérez, F.A., Dyballa, S., Coppe, B., Mercader Huber, N., Terriente, J., Di Donato, V. (2024) ZebraReg-a novel platform for discovering regulators of cardiac regeneration using zebrafish. Frontiers in cell and developmental biology. 12:13844231384423
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Vignes, H., Vagena-Pantoula, C., Prakash, M., Fukui, H., Norden, C., Mochizuki, N., Jug, F., Vermot, J. (2022) Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Developmental Cell. 57(5):598-609.e5
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Chen, Y., Wang, H., Wang, F., Chen, C., Zhang, P., Song, D., Luo, T., Xu, H., Zeng, X. (2020) Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Theriogenology. 151:41-51
- Gross-Thebing, S., Truszkowski, L., Tenbrinck, D., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, B.E., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., Raz, E. (2020) Using migrating cells as probes to illuminate features in live embryonic tissues. Science advances. 6(49):
- Liu, S.T., Chou, M.Y., Wu, L.C., Horng, J.L., Lin, L.Y. (2020) Transient receptor potential vanilloid 4 modulates ion balance through the isotocin pathway in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 318(4):R751-R759
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Duchemin, A.L., Vignes, H., Vermot, J. (2019) Mechanically activated Piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis. eLIFE. 8:
- Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:
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