Gene
ndrg1a
- ID
- ZDB-GENE-030826-34
- Name
- N-myc downstream regulated 1a
- Symbol
- ndrg1a Nomenclature History
- Previous Names
-
- ndrg1
- cb775 (1)
- wu:fb60h02
- zgc:63944
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of cellular response to hypoxia. Predicted to be active in cytoplasm. Is expressed in several structures, including caudal vein plexus; corpuscles of Stannius; integument; pleuroperitoneal region; and visual system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb775 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Takita et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ndrg1a | Park et al., 2022 | |
| CRISPR2-ndrg1a | Park et al., 2022 | |
| CRISPR3-ndrg1a | Park et al., 2022 | |
| CRISPR4-ndrg1a | Zebrafish Nomenclature Committee | |
| MO1-ndrg1a | N/A | Takita et al., 2016 |
| MO2-ndrg1a | N/A | Park et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 4D | Alliance | Charcot-Marie-Tooth disease, type 4D | 601455 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | NDRG |
|---|---|---|---|---|
| UniProtKB:Q6A3P5 | InterPro | 392 | ||
| UniProtKB:A5WW18 | InterPro | 379 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndrg1a-201
(1)
|
Ensembl | 2,353 nt | ||
| mRNA |
ndrg1a-202
(1)
|
Ensembl | 2,301 nt | ||
| ncRNA |
ndrg1a-003
(1)
|
Ensembl | 849 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ndrg1a | Mouse |
|
1 | ||||
| Ab2-ndrg1a | Mouse |
|
1 | ||||
| Ab3-ndrg1a | Mouse |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(rho:ndrg1a-IRES-mSEGFP-CAAX) |
| 1 | Takita et al., 2016 | ||
| Tg(rho:ndrg1a-IRES-mSEGFP-CAAX) |
| 1 | Takita et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-38F10 | ZFIN Curated Data | |
| Encodes | EST | cb775 | Thisse et al., 2001 | |
| Encodes | EST | fb60h02 | ||
| Encodes | cDNA | MGC:63944 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213348 (1) | 2353 nt | ||
| Genomic | GenBank:CT573122 (2) | 111064 nt | ||
| Polypeptide | UniProtKB:Q6A3P5 (1) | 392 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Park, J.S., Gabel, A.M., Kassir, P., Kang, L., Chowdhary, P.K., Osei-Ntansah, A., Tran, N.D., Viswanathan, S., Canales, B., Ding, P., Lee, Y.S., Brewster, R. (2022) N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLIFE. 11:
- Le, N., Hufford, T.M., Park, J.S., Brewster, R.M. (2021) Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21961
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kuechlin, S., Schoels, M., Slanchev, K., Lassmann, S., Walz, G., Yakulov, T.A. (2017) EpCAM controls morphogenetic programs during zebrafish pronephros development. Biochemical and Biophysical Research Communications. 487(2):209-215
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Crippa, S., Nemir, M., Ounzain, S., Ibberson, M., Berthonneche, C., Sarre, A., Boisset, G., Maison, D., Harshman, K., Xenarios, I., Diviani, D., Schorderet, D., Pedrazzini, T. (2016) Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovascular research. 110(1):73-84
- Li, R.A., Traver, D., Matthes, T., Bertrand, J.Y. (2016) Ndrg1b and fam49ab modulate the PTEN pathway to control T cell lymphopoiesis in the zebrafish. Blood. 128(26):3052-3060
- Takita, S., Wada, Y., Kawamura, S. (2016) Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish. Scientific Reports. 6:36590
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