Gene
zic3
- ID
- ZDB-GENE-030708-2
- Name
- zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
- Symbol
- zic3 Nomenclature History
- Previous Names
-
- cb807 (1)
- id:ibd2176
- wu:fj52a10
- wu:fq33c12
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior axis specification and determination of left/right symmetry. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesoderm; neural keel; neural plate; and presumptive structure. Used to study right atrial isomerism; spina bifida; and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; visceral heterotaxy 1; and visceral heterotaxy 5. Orthologous to human ZIC3 (Zic family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb807 (25 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-zic3 | (2) | |
CRISPR2-zic3 | (2) | |
CRISPR3-zic3 | (2) | |
CRISPR4-zic3 | (2) | |
CRISPR5-zic3 | (2) | |
CRISPR6-zic3 | (2) | |
CRISPR7-zic3 | (2) | |
CRISPR8-zic3 | (2) | |
CRISPR9-zic3 | (2) | |
MO1-zic3 | N/A | Cast et al., 2012 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
visceral heterotaxy 1 | Alliance | Congenital heart defects, nonsyndromic, multiple types, 1, X-linked | 306955 |
visceral heterotaxy 1 | Alliance | Heterotaxy, visceral, 1, X-linked | 306955 |
X-linked VACTERL association | Alliance | VACTERL association, X-linked | 314390 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
right atrial isomerism | TU + MO4-zic3 | standard conditions | Li et al., 2018 |
spina bifida | AB + MO1-zic3 | standard conditions | Cast et al., 2012 |
visceral heterotaxy | AB + MO1-zic3 | standard conditions | Cast et al., 2012 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC1-5/GLI1-3like, C2H2 zinc finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|---|---|---|
UniProtKB:Q6PV84 | InterPro | 448 |
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Interactions and Pathways
No data available
Plasmids
No data available
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-69B22 | ZFIN Curated Data | |
Encodes | EST | cb807 | Thisse et al., 2001 | |
Encodes | EST | fj52a10 | ZFIN Curated Data | |
Encodes | EST | fq33c12 | Rauch et al., 2003 | |
Encodes | EST | ibd2176 | ZFIN Curated Data | |
Encodes | cDNA | MGC:113891 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001001950 (1) | 2950 nt | ||
Genomic | GenBank:BX511142 (1) | 168322 nt | ||
Polypeptide | UniProtKB:Q6PV84 (1) | 448 aa |
- Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
- Talbot, C.D., Walsh, M.D., Cutty, S.J., Elsayed, R., Vlachaki, E., Bruce, A.E.E., Wardle, F.C., Nelson, A.C. (2022) Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Frontiers in cell and developmental biology. 10:982477
- Sun, Y., Yang, F., Liu, Y., Yu, M., Wu, F., Wang, G. (2021) Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development. Toxicology and industrial health. 37(7):391-397
- Kumar, A., Anuppalle, M., Maddirevula, S., Huh, T.L., Choe, J., Rhee, M. (2019) Peli1b governs the brain patterning via ERK signaling pathways in zebrafish embryos. Gene. 694:1-6
- Minhas, R., Paterek, A., Łapiński, M., Bazała, M., Korzh, V., Winata, C.L. (2019) A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(9):837-849
- Li, S., Liu, S., Chen, W., Yuan, Y., Gu, R., Song, Y., Li, J., Cao, Y., Lin, Y., Xu, J., Wang, H., Ma, D., Ma, X., Sheng, W., Huang, G. (2018) A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease. Scientific Reports. 8:12386
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Ota, S., Taimatsu, K., Yanagi, K., Namiki, T., Ohga, R., Higashijima, S.I., Kawahara, A. (2016) Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Scientific Reports. 6:34991
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
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