Gene
grk3
- ID
- ZDB-GENE-030616-382
- Name
- G protein-coupled receptor kinase 3
- Symbol
- grk3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables protein kinase activity. Acts upstream of or within several processes, including heart rudiment formation; muscle cell development; and smoothened signaling pathway. Predicted to be located in presynapse. Is expressed in several structures, including heart; immature eye; nervous system; notochord; and tail bud. Orthologous to human GRK3 (G protein-coupled receptor kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
i283 | Allele with one deletion | Unknown | Frameshift | zinc finger nuclease | |
sa2558 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa2560 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa5588 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-grk3 | Bu et al., 2021 | |
CRISPR2-grk3 | Casey et al., 2024 | |
CRISPR3-grk3 | Casey et al., 2024 | |
CRISPR4-grk3 | Casey et al., 2024 | |
MO1-grk3 | N/A | (6) |
MO2-grk3 | N/A | Jiang et al., 2009 |
MO3-grk3 | N/A | Philipp et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B5LZ08 | InterPro | 688 | |||||||||||
UniProtKB:A0A2R8QPB8 | InterPro | 701 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-grk3 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
4 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-142E17 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-221D18 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001134725 (1) | 2067 nt | ||
Genomic | GenBank:FO704775 (1) | 103561 nt | ||
Polypeptide | UniProtKB:A0A2R8QPB8 (1) | 701 aa |
- Casey, M.J., Chan, P.P., Li, Q., Zu, J.F., Jette, C.A., Kohler, M., Myers, B.R., Stewart, R.A. (2024) A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma. Cell Reports. 43:114559114559
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
- Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D. (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Journal of Molecular and Cellular Cardiology. 108:95-105
- Zhao, Z., Lee, R.T., Pusapati, G.V., Iyu, A., Rohatgi, R., Ingham, P.W. (2016) An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO reports. 17(5):739-52
- Burczyk, M.S., Burkhalter, M.D., Blätte, T., Matysik, S., Caron, M.G., Barak, L.S., Philipp, M. (2015) Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2. Biochemistry. 54(3):765-75
- Philipp, M., Berger, I.M., Just, S., Caron, M.G. (2014) Overlapping and Opposing Functions of GRK2 and GRK5 during Heart Development. The Journal of biological chemistry. 289(38):26119-30
- Burkhalter, M.D., Fralish, G.B., Premont, R.T., Caron, M.G., and Philipp, M. (2013) Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking. Cell Reports. 4(4):625-632
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