Gene
dusp6
- ID
- ZDB-GENE-030613-1
- Name
- dual specificity phosphatase 6
- Symbol
- dusp6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables phosphoprotein phosphatase activity. Acts upstream of or within several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to be active in cytosol. Is expressed in several structures, including brain; fin; germ ring; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| pt30a | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| pt30b | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| pt30c | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| pt30d | Allele with one insertion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| sa24648 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| um239 | Allele with one delins | Unknown | Unknown | CRISPR | |
| um286 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dusp6 | Maurer et al., 2018 | |
| CRISPR2-dusp6 | Maurer et al., 2018 | |
| MO1-dusp6 | N/A | van Boxtel et al., 2017 |
| MO2-dusp6 | N/A | van Boxtel et al., 2017 |
| MO3-dusp6 | N/A | Maurer et al., 2018 |
| TALEN1-dusp6 | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 19 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 19 with or without anosmia | 615269 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Family | IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2L8 | InterPro | 382 |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dusp6 | monoclonal | IgG1 , k | Mouse |
|
Sigma-Aldrich
|
4 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(dusp6:d2EGFP) |
|
| 5 | (44) | |
| Tg(dusp6:GFP-MA) |
|
| 1 | (8) | |
| Tg(dusp6:Cre-ERT2,myl7:ECFP) |
|
| 1 | (3) | |
| Tg(dusp6:GAL4-ERT2-VP16,myl7:ECFP) |
|
| 1 | (2) | |
| Tg(dusp6:MA-GFP) |
|
| 1 | (3) | |
| Tg(hsp70l:dusp6) |
|
| 1 | (2) | |
| Tg(UAS:NLS-Tomato-2A-dusp6) |
| 1 | Shin et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-164B12 | ZFIN Curated Data | |
| Encodes | EST | fd99d09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73342 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77006 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194380 (1) | 2937 nt | ||
| Genomic | GenBank:AL954645 (1) | 182141 nt | ||
| Polypeptide | UniProtKB:Q7T2L8 (1) | 382 aa |
- Wang, Z.Y., Mehra, A., Wang, Q.C., Gupta, S., Ribeiro da Silva, A., Juan, T., Günther, S., Looso, M., Detleffsen, J., Stainier, D.Y.R., Marín-Juez, R. (2024) flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. Development (Cambridge, England). 151(23):
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Brown, W., Bardhan, A., Darrah, K., Tsang, M., Deiters, A. (2022) Optical Control of MicroRNA Function in Zebrafish Embryos. Journal of the American Chemical Society. 144(37):16819-16826
- Phelps, G.B., Hagen, H.R., Amsterdam, A., Lees, J.A. (2022) MITF deficiency accelerates GNAQ-driven uveal melanoma. Proceedings of the National Academy of Sciences of the United States of America. 119:e2107006119
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Lüffe, T.M., D'Orazio, A., Bauer, M., Gioga, Z., Schoeffler, V., Lesch, K.P., Romanos, M., Drepper, C., Lillesaar, C. (2021) Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Translational psychiatry. 11:529
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Reuter, I., Jäckels, J., Kneitz, S., Kuper, J., Lesch, K.P., Lillesaar, C. (2019) Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish. Biology Open. 8(6):
- Bellesso, S., Salvalaio, M., Lualdi, S., Tognon, E., Costa, R., Braghetta, P., Giraudo, C., Stramare, R., Rigon, L., Filocamo, M., Tomanin, R., Moro, E. (2018) FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII). Human molecular genetics. 27:2262-2275
- Fernandes, S.F., Fior, R., Pinto, F., Gama-Carvalho, M., Saúde, L. (2018) Fine-tuning of fgf8a expression through alternative polyadenylation has a selective impact on Fgf-associated developmental processes. Biochimica et biophysica acta.
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