Gene

mgaa

ID
ZDB-GENE-030603-1
Name
MAX dimerization protein MGA a
Symbol
mgaa Nomenclature History
Previous Names
  • mga
  • im:7137698
  • sb:eu601
  • wu:fd99g02
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; determination of bilateral symmetry; and positive regulation of BMP signaling pathway. Part of SMAD protein complex. Is expressed in several structures, including gut; head; pectoral fin bud; and yolk syncytial layer. Orthologous to human MGA (MAX dimerization protein MGA).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb801Allele with one deletionExon 2Frameshift, Premature StopTALEN
sa865Allele with one point mutationUnknownPremature StopENU
sa9048Allele with one point mutationUnknownPremature StopENU
sa18203Allele with one point mutationUnknownPremature StopENU
sa36332Allele with one point mutationUnknownPremature StopENU
sa36333Allele with one point mutationUnknownPremature StopENU
sa39148Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With mgaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Premature ovarian failure 26 621065
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Associated With mgaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR032060 MGA, conserved domain
Domain IPR046360 T-box transcription factor, DNA-binding domain
Family IPR001699 T-box transcription factor
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Helix-loop-helix DNA-binding domain superfamily MGA, conserved domain p53-like transcription factor, DNA-binding domain superfamily T-box superfamily T-box transcription factor T-box transcription factor, DNA-binding domain Transcription factor, T-box, conserved site
UniProtKB:A0A8M2B518 InterPro 2811
UniProtKB:D2JVK2 InterPro 2735
UniProtKB:A0A8M2B5I7 InterPro 2838
UniProtKB:F1R7N7 InterPro 2735
UniProtKB:A0A8M2B523 InterPro 2837
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mgaa-201 (1) Ensembl 11,692 nt
mRNA mgaa-202 (1) Ensembl 538 nt
mRNA mgaa-203 (1) Ensembl 11,931 nt
mRNA mgaa-204 (1) Ensembl 251 nt
mRNA mgaa-205 (1) Ensembl 11,914 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-mgaa
1
Ab1-mgaa
  • IHC
1
Ab2-mgaa
  • IHC
1
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-89F23ZFIN Curated Data
ContainsSNPrs3728833
    ZFIN Curated Data
    EncodesESTeu601Thisse et al., 2005
    EncodesESTfd99g02
    EncodesESTIMAGE:7137698Thisse et al., 2004
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanMGA15
    Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    MouseMga2
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (2)
    Citations
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