tg

ID

ZDB-GENE-030519-1

Name

thyroglobulin

Symbol

tg Nomenclature History

Previous Names

cb717 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone activity. Acts upstream of or within regulation of thyroid hormone generation. Located in extracellular region. Is expressed in pharyngeal arch; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in autoimmune disease of endocrine system (multiple); goiter; liver disease (multiple); and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

51 figures from 26 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb717 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Song et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thyroid dyshormonogenesis 3	Alliance	Thyroid dyshormonogenesis 3	274700
		{Autoimmune thyroid disease, susceptibility to, 3}	608175

Associated With tg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR002018	Carboxylesterase, type B
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Family	IPR052001	MHC Class II Gamma Chain/Thyroglobulin
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily