Gene
sp5a
- ID
- ZDB-GENE-030430-2
- Name
- Sp5 transcription factor a
- Symbol
- sp5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within mesoderm morphogenesis and otolith formation. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; margin; neural plate; otic vesicle; and tail bud. Orthologous to human SP5 (Sp5 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tan et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-sp5a | Tan et al., 2022 | |
MO1-sp5a | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|
UniProtKB:B0S6I8 | InterPro | 368 |
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Interactions and Pathways
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-88M1 | ZFIN Curated Data | |
Contained in | BAC | DKEY-249G23 | ZFIN Curated Data | |
Encodes | EST | fc39b01 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194009 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194038 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_180973 (1) | 3115 nt | ||
Genomic | GenBank:CR394567 (2) | 189488 nt | ||
Polypeptide | UniProtKB:B0S6I8 (1) | 368 aa |
- Ali, M., Kutlowski, J.W., Holland, J.N., Riley, B.B. (2025) Foxm1 promotes differentiation of neural progenitors in the zebrafish inner ear. Developmental Biology. 520:213021-30
- Bell, I., Khan, H., Stutt, N., Horn, M., Hydzik, T., Lum, W., Rea, V., Clapham, E., Hoeg, L., Van Raay, T.J. (2024) Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Molecular biology of the cell. 35(7):ar93
- Rea, V., Bell, I., Ball, T., Van Raay, T. (2022) Gut-derived metabolites influence neurodevelopmental gene expression and Wnt signaling events in a germ-free zebrafish model. Microbiome. 10:132
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Wint, J.M., Sirotkin, H.I. (2020) Lrrk2 modulation of Wnt signaling during zebrafish development. Journal of neuroscience research. 98(10):1831-1842
- Vogg, M.C., Beccari, L., Iglesias Ollé, L., Rampon, C., Vriz, S., Perruchoud, C., Wenger, Y., Galliot, B. (2019) An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra. Nature communications. 10:312
- Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Labalette, C., Wassef, M.A., Desmarquet-Trin Dinh, C., Bouchoucha, Y.X., Le Men, J., Charnay, P., Gilardi-Hebenstreit, P. (2015) Molecular dissection of segment formation in the developing hindbrain. Development (Cambridge, England). 142:185-95
- Superina, S., Borovina, A., and Ciruna, B. (2014) Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry. Developmental Biology. 387(2):154-166
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