Gene
avp
- ID
- ZDB-GENE-030407-2
- Name
- arginine vasopressin
- Symbol
- avp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable neuropeptide hormone activity. Predicted to be involved in intracellular signal transduction. Located in axon hillock. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in diabetes insipidus; neurohypophyseal diabetes insipidus; opioid abuse; and schizophrenia. Orthologous to human AVP (arginine vasopressin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-avp | Ramachandran et al., 2023 | |
| CRISPR2-avp | Ramachandran et al., 2023 | |
| MO1-avp | N/A | Herget et al., 2014 |
| MO2-avp | N/A | Tong et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurohypophyseal diabetes insipidus | Alliance | Diabetes insipidus, neurohypophyseal | 125700 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Neurohypophysial hormone | Neurohypophysial hormone, conserved site | Neurohypophysial hormone domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q8AV79 | InterPro | 149 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(avp:KALTA4) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-129K1 | ZFIN Curated Data | |
| Encodes | EST | fj35h07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178293 (1) | 540 nt | ||
| Genomic | GenBank:CU896541 (1) | 104170 nt | ||
| Polypeptide | UniProtKB:Q8AV79 (1) | 149 aa |
- Castillo-Ramírez, L.A., Herget, U., Ryu, S., De Marco, R.J. (2024) Early-life challenge enhances cortisol regulation in zebrafish larvae. Biology Open. 13(12):
- Zanardini, M., Zhang, W., Habibi, H.R. (2024) Arginine Vasotocin Directly Regulates Spermatogenesis in Adult Zebrafish (Danio rerio) Testes. International Journal of Molecular Sciences. 25(12):
- Lin, C.Y., Yeh, K.Y., Lai, H.H., Her, G.M. (2023) AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish. Biomedicines. 11(2):
- Ramachandran, D., Sharma, K., Saxena, V., Nipu, N., Rajapaksha, D.C., Mennigen, J.A. (2023) Knock-out of vasotocin reduces reproductive success in female zebrafish, Danio rerio. Frontiers in endocrinology. 14:11512991151299
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
- Kawabe, M., Nishida, T., Horita, C., Ikeda, A., Takahashi, R., Inui, A., Shiozaki, K. (2022) Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish. Frontiers in pharmacology. 13:905711
- Salahinejad, A., Attaran, A., Meuthen, D., Rachamalla, M., Chivers, D.P., Niyogi, S. (2022) Maternal exposure to bisphenol S induces neuropeptide signaling dysfunction and oxidative stress in the brain, and abnormal social behaviors in zebrafish (Danio rerio) offspring. The Science of the total environment. 830:154794
- Ariyasiri, K., Choi, T.I., Gerlai, R., Kim, C.H. (2021) Acute ethanol induces behavioral changes and alters c-fos expression in specific brain regions, including the mammillary body, in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 109:110264
- Ikeda, A., Komamizu, M., Hayashi, A., Yamasaki, C., Okada, K., Kawabe, M., Komatsu, M., Shiozaki, K. (2021) Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Reports. 11:13477
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