Gene
dio2
- ID
- ZDB-GENE-030327-4
- Name
- iodothyronine deiodinase 2
- Symbol
- dio2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables thyroxine 5'-deiodinase activity. Acts upstream of or within several processes, including chordate embryonic development; developmental pigmentation; and regulation of neural retina development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; hypophysis; male organism; and thyroid follicle. Used to study glucose metabolism disease and hypothyroidism. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73279 (1 image)
- cb684 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 27 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dio2 | Aman et al., 2021 | |
| MO1-dio2 | N/A | (7) |
| MO2-dio2 | N/A | Walpita et al., 2009 |
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Human Disease
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Iodothyronine deiodinase | Iodothyronine deiodinase, active site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6PBR8 | InterPro | 257 | |||
| UniProtKB:A0A8N7V0B4 | InterPro | 258 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-245F17 | ZFIN Curated Data | |
| Contains | STS | chunp30595 | ||
| Encodes | EST | cb684 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:73279 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212789 (1) | 2219 nt | ||
| Genomic | GenBank:CR381576 (1) | 185749 nt | ||
| Polypeptide | UniProtKB:A0A8N7V0B4 (1) | 258 aa |
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
- Dai, X., Pradhan, A., Liu, J., Liu, R., Zhai, G., Zhou, L., Dai, J., Shao, F., Yuan, Z., Wang, Z., Yin, Z. (2023) Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions. Biology of sex differences. 14:5353
- Grinberg, L., Dabbah Assadi, F., Baum, G., Zemel, R., Tur-Kaspa, R., Shochat, C., Karasik, D., Karpuj, M.V. (2023) Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model. Nutrients. 15(6):
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Yang, L., Tu, P.H., Zhang, C.X., Xie, R.R., Dong, M., Jing, Y., Chen, X., Wei, G., Song, H.D. (2023) Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae. Frontiers in endocrinology. 14:12046781204678
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