Gene

dio2

ID
ZDB-GENE-030327-4
Name
iodothyronine deiodinase 2
Symbol
dio2 Nomenclature History
Previous Names
  • D2 (1)
  • Deio2 (1)
  • cb684 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables thyroxine 5'-deiodinase activity. Acts upstream of or within several processes, including chordate embryonic development; developmental pigmentation; and regulation of neural retina development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; hypophysis; male organism; and thyroid follicle. Used to study glucose metabolism disease and hypothyroidism. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
32 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
lv1Allele with one deletionUnknownUnknownzinc finger nuclease
lv2Allele with one insertionUnknownFrameshift, Premature Stopzinc finger nuclease
vp42rc1Allele with one delinsExon 1UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-dio2Aman et al., 2021
MO1-dio2N/A (7)
MO2-dio2N/AWalpita et al., 2009
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Human Disease
Associated With dio2 Human Ortholog
No data available
Associated With dio2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008261 Iodothyronine deiodinase, active site
Family IPR000643 Iodothyronine deiodinase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Iodothyronine deiodinase Iodothyronine deiodinase, active site Thioredoxin-like superfamily
UniProtKB:Q6PBR8 InterPro 257
UniProtKB:A0A8N7V0B4 InterPro 258
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dio2-201 (1) Ensembl 2,166 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dio2 polyclonal Rabbit
  • WB
1
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Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-245F17ZFIN Curated Data
ContainsSTSchunp30595
EncodesESTcb684Thisse et al., 2001
EncodescDNAMGC:73279ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDIO214
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseDio212
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 191
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