Gene
llgl2
- ID
- ZDB-GENE-030131-9877
- Name
- LLGL scribble cell polarity complex component 2
- Symbol
- llgl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and myosin II binding activity. Acts upstream of or within with a positive effect on cell projection assembly. Acts upstream of or within several processes, including Kupffer's vesicle development; hemidesmosome assembly; and photoreceptor cell morphogenesis. Predicted to be located in cytoskeleton. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including EVL; Kupffer's vesicle; digestive system; mesoderm; and sensory system. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb521 (18 images)
- IMAGE:7154746 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012203Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018226Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa31887 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38900 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| to6 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-llgl2 | Hatzold et al., 2023 | |
| CRISPR2-llgl2 | Hatzold et al., 2023 | |
| CRISPR3-llgl2 | Lin et al., 2025 | |
| CRISPR4-llgl2 | Lin et al., 2025 | |
| CRISPR5-llgl2 | Lin et al., 2025 | |
| MO1-llgl2 | N/A | (11) |
| MO2-llgl2 | N/A | Hava et al., 2009 |
| MO3-llgl2 | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013577 | Lethal giant larvae homologue 2 |
| Family | IPR000664 | Lethal(2) giant larvae protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Lethal(2) giant larvae protein | Lethal giant larvae homologue 2 | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZE3 | InterPro | 1020 | |||||
| UniProtKB:B7ZVM2 | InterPro | 1020 | |||||
| UniProtKB:A0A8M9QMN2 | InterPro | 1004 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-77C22 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-67E6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-342O4 | ZFIN Curated Data | |
| Encodes | EST | cb521 | Thisse et al., 2001 | |
| Encodes | EST | fc06g08 | ZFIN Curated Data | |
| Encodes | EST | fl37c09 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7154746 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55895 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198362 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212582 (1) | 4287 nt | ||
| Genomic | GenBank:CR405682 (1) | 192457 nt | ||
| Polypeptide | UniProtKB:B7ZVM2 (1) | 1020 aa |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Arora, P., Dongre, S., Raman, R., Sonawane, M. (2020) Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish. eLIFE. 9:
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Kujawski, S., Sonawane, M., Knust, E. (2019) penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina. Biology Open. 8(4):
- Magre, I., Fandade, V., Damle, I., Banerjee, P., Yadav, S.K., Sonawane, M., Joseph, J. (2019) Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis. Journal of Cell Science. 132(12):
- Dasgupta, A., Merkel, M., Clark, M.J., Jacob, A.E., Dawson, J.E., Manning, M.L., Amack, J.D. (2018) Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle. eLIFE. 7
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hatzold, J., Beleggia, F., Herzig, H., Altmüller, J., Nürnberg, P., Bloch, W., Wollnik, B., Hammerschmidt, M. (2016) Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLIFE. 5:e14277
- Ji, Y., Buel, S.M., Amack, J.D. (2016) Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs. Developmental Biology. 416(1):69-81
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