Gene
hmcn2
- ID
- ZDB-GENE-030131-9765
- Name
- hemicentin 2
- Symbol
- hmcn2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including embryonic medial fin morphogenesis; mesenchymal cell migration; and skin morphogenesis. Predicted to be located in extracellular region and plasma membrane. Is expressed in several structures, including axis; median fin fold; mesoderm; myotome; and trunk.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb30 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13006 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16664 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31666 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa34441 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34442 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41251 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa41252 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41253 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44691 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hmcn2 | N/A | (2) |
| MO2-hmcn2 | N/A | Carney et al., 2010 |
| MO3-hmcn2 | N/A | Martins Feitosa et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cellular adhesion and signaling domain-containing protein | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | G2 nidogen/fibulin G2F | Green fluorescent protein | Growth factor receptor cysteine-rich domain superfamily | Hemicentin/VWA7, galactose-binding domain-like | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | NOTCH1 EGF-like calcium-binding domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EY71 | InterPro | 1126 | |||||||||||||||||||||
| UniProtKB:E7F3V2 | InterPro | 4212 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-204C5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-164F24 | ZFIN Curated Data | |
| Encodes | EST | cb30 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001920466 (1) | 13770 nt | ||
| Genomic | GenBank:BX548021 (2) | 202392 nt | ||
| Polypeptide | UniProtKB:E7F3V2 (1) | 4212 aa |
- Comparative Orthology
- Alliance
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Liedtke, D., Orth, M., Meissler, M., Geuer, S., Knaup, S., Köblitz, I., Klopocki, E. (2019) ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects. Scientific Reports. 9:13383
- Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lee, R.T., Knapik, E.W., Thiery, J.P., and Carney, T.J. (2013) An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme. Development (Cambridge, England). 140(14):2923-2932
- Martins Feitosa, N., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W., and Hammerschmidt, M. (2012) Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development. Developmental Biology. 369(2):235-248
- Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
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